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Comparative analysis of IL-8 and CXCL-1 production by normal and cancer stromal fibroblasts
P. Szabo, J. Valach, K. Smetana, B. Dvořánková
Language English Country Czech Republic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
Grant support
NT13488
MZ0
CEP Register
Digital library NLK
Full text - Article
Source
NLK
Free Medical Journals
from 2000
Freely Accessible Science Journals
from 2000
ProQuest Central
from 2005-01-01
Health & Medicine (ProQuest)
from 2005-01-01
ROAD: Directory of Open Access Scholarly Resources
from 2000
- MeSH
- Stromal Cells secretion MeSH
- Chemokine CXCL1 secretion MeSH
- Fibroblasts secretion MeSH
- Wound Healing physiology MeSH
- Interleukin-8 secretion MeSH
- Keratinocytes physiology MeSH
- Coculture Techniques MeSH
- Culture Media, Conditioned MeSH
- Cells, Cultured MeSH
- Humans MeSH
- Neoplasm Proteins secretion MeSH
- Hypopharyngeal Neoplasms pathology secretion MeSH
- Skin Neoplasms pathology secretion MeSH
- Secretory Rate MeSH
- Dermis cytology MeSH
- Carcinoma, Squamous Cell pathology secretion MeSH
- Up-Regulation MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
It has been shown that fibroblasts within the stroma of malignant tumours can affect the tumour's biological character, influencing such properties as local aggressiveness and metastasis potential. This influence is asserted via paracrine secretion of multiple cell factors, including chemokines. This study demonstrates that both normal keratinocytes and cancer cells can stimulate the secretion of chemokines IL-8 and CXCL-1 from normal dermal fibroblasts and stromal fibroblasts from squamous cell carcinoma. The effect of epithelia on normal fibroblasts leads to a transient secretory change, in contrast to stromal fibroblasts which generate a more prolonged one. This observation demonstrates that stimulated expression of both IL-8 and CXCL-1 is not specific to cancer, supporting the hypothesis that similar mechanisms exist between wound healing and oncogenesis. It also shows that stromal fibroblasts isolated from a tumour have significantly different features from normal fibroblasts.
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- $a It has been shown that fibroblasts within the stroma of malignant tumours can affect the tumour's biological character, influencing such properties as local aggressiveness and metastasis potential. This influence is asserted via paracrine secretion of multiple cell factors, including chemokines. This study demonstrates that both normal keratinocytes and cancer cells can stimulate the secretion of chemokines IL-8 and CXCL-1 from normal dermal fibroblasts and stromal fibroblasts from squamous cell carcinoma. The effect of epithelia on normal fibroblasts leads to a transient secretory change, in contrast to stromal fibroblasts which generate a more prolonged one. This observation demonstrates that stimulated expression of both IL-8 and CXCL-1 is not specific to cancer, supporting the hypothesis that similar mechanisms exist between wound healing and oncogenesis. It also shows that stromal fibroblasts isolated from a tumour have significantly different features from normal fibroblasts.
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- $w MED00011004 $t Folia biologica $x 0015-5500 $g Roč. 59, č. 3 (2013), s. 134-137
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- $u https://fb.cuni.cz/file/5691/FB2013A0018.pdf $y plný text volně přístupný
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