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Proconvulsant action of two GABA(B) receptor antagonists is age-dependent
P. Mareš
Language English Country Czech Republic
Document type Journal Article, Research Support, Non-U.S. Gov't
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- MeSH
- Action Potentials drug effects MeSH
- GABA-B Receptor Antagonists pharmacology MeSH
- Electroencephalography MeSH
- Epilepsies, Myoclonic chemically induced physiopathology MeSH
- Injections, Intraperitoneal MeSH
- Convulsants MeSH
- Rats MeSH
- Phosphinic Acids pharmacology MeSH
- Disease Models, Animal * MeSH
- Cerebral Cortex drug effects physiopathology MeSH
- Rats, Wistar MeSH
- Propanolamines pharmacology MeSH
- Receptors, GABA physiology MeSH
- Aging MeSH
- Drug Synergism MeSH
- Age Factors MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Antagonists of GABA(B) receptors are expected to have proconvulsant action also in developing brain. Two antagonists (CGP55845 and CGP46381) were tested in a model of cortical epileptic afterdischarges (ADs) in 12-, 18- and 25-day-old rat pups with implanted electrodes. CGP55845 was dissolved in dimethylsulfoxide and the results demonstrated marked proconvulsant action of this solvent which masked possible action of the antagonist. Water soluble antagonist CGP46381 led to marked potentiation of ADs in 12-day-old animals, its action decreased with age, it was negligible in 25-day-old rats. Our results demonstrated important inhibitory role of GABA(B) receptors at very early stages of maturation.
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