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p16- og p53-generne overført ved hjaelp af adenovirus samarbejder for at inducere apoptotisk tumorcelledød [p16 and p53 genes transferred with the help of adenovirus to induce apoptic tumor cell death]

BV. Sandig, K. Brand, S. Herwig, J. Lukas, J. Bartek, M. Strauss,

. 1997 ; 159 (46) : 6825-6830.

Language Danish Country Denmark

Document type English Abstract, Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc15000998

Based on studies of the cell cycle in tissue cultures of cancer cell lines and cells from normal tissue interference in the regulatory network of pRB/cdk4/cyclin D1/p16 in combination with the tumour suppressor gene p53 was investigated. It was shown that overexpression of p53 and p16, but not p53 on its own, induced apoptotic cell death only in tumour cells. Gene transfer of the same two genes to tumours transplanted subcutaneously in mice also caused fast regression of some of the tumours.

p16 and p53 genes transferred with the help of adenovirus to induce apoptic tumor cell death

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