-
Something wrong with this record ?
Electrochemical study of ellipticine interaction with single and double stranded oligonucleotides
K. Tmejova, L. Krejcova, D. Hynek, V. Adam, P. Babula, L. Trnkova, M. Stiborova, T. Eckschlager, R. Kizek,
Language English Country Netherlands
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Apocynaceae chemistry MeSH
- Electrochemical Techniques MeSH
- Ellipticines chemistry MeSH
- Oligonucleotides chemistry MeSH
- Antineoplastic Agents chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is an alkaloid that has been isolated from plants of an Apocynaceae family. It is one of the simplest naturally occurring alkaloids with a planar structure. Over the past decades, ellipticine became a very promising antitumor agent. Interaction with DNA is one of the most studied ellipticine effects on cell division. This phenomenon is not clearly explained so far. In our experiments we studied interaction of ellipticine with single-stranded and double-stranded oligonucleotides by electrochemical methods on mercury electrode. Differential pulse voltammetry was applied for ellipticine (Elli) and CA peak detection. Square wave voltammetry was applied for G peak detection. The effect of the interaction time and ellipticine concentrations on interactions of ellipticine with single- and double-stranded oligonucleotides was tested too.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc15008590
- 003
- CZ-PrNML
- 005
- 20150310124648.0
- 007
- ta
- 008
- 150306s2014 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.2174/18715206113139990316 $2 doi
- 035 __
- $a (PubMed)23869776
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Tmejova, Katerina
- 245 10
- $a Electrochemical study of ellipticine interaction with single and double stranded oligonucleotides / $c K. Tmejova, L. Krejcova, D. Hynek, V. Adam, P. Babula, L. Trnkova, M. Stiborova, T. Eckschlager, R. Kizek,
- 520 9_
- $a Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is an alkaloid that has been isolated from plants of an Apocynaceae family. It is one of the simplest naturally occurring alkaloids with a planar structure. Over the past decades, ellipticine became a very promising antitumor agent. Interaction with DNA is one of the most studied ellipticine effects on cell division. This phenomenon is not clearly explained so far. In our experiments we studied interaction of ellipticine with single-stranded and double-stranded oligonucleotides by electrochemical methods on mercury electrode. Differential pulse voltammetry was applied for ellipticine (Elli) and CA peak detection. Square wave voltammetry was applied for G peak detection. The effect of the interaction time and ellipticine concentrations on interactions of ellipticine with single- and double-stranded oligonucleotides was tested too.
- 650 _2
- $a protinádorové látky $x chemie $7 D000970
- 650 _2
- $a Apocynaceae $x chemie $7 D029062
- 650 _2
- $a elektrochemické techniky $7 D055664
- 650 _2
- $a elipticiny $x chemie $7 D004611
- 650 _2
- $a oligonukleotidy $x chemie $7 D009841
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Krejcova, Ludmila
- 700 1_
- $a Hynek, David
- 700 1_
- $a Adam, Vojtěch $7 xx0064599
- 700 1_
- $a Babula, Petr
- 700 1_
- $a Trnkova, Libuse
- 700 1_
- $a Stiborova, Marie
- 700 1_
- $a Eckschlager, Tomas
- 700 1_
- $a Kizek, Rene $u Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic, European Union. kizek@sci.muni.cz.
- 773 0_
- $w MED00172590 $t Anti-cancer agents in medicinal chemistry $x 1875-5992 $g Roč. 14, č. 2 (2014), s. 331-40
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/23869776 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20150306 $b ABA008
- 991 __
- $a 20150310124925 $b ABA008
- 999 __
- $a ok $b bmc $g 1065863 $s 891390
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2014 $b 14 $c 2 $d 331-40 $i 1875-5992 $m Anti-cancer agents in medicinal chemistry $n Anticancer Agents Med Chem $x MED00172590
- LZP __
- $a Pubmed-20150306
