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Access to bifunctionalized biomolecular platforms using oxime ligation

K. Křenek, R. Gažák, GC. Daskhan, J. Garcia, M. Fiore, P. Dumy, M. Sulc, V. Křen, O. Renaudet,

. 2014 ; 393 (-) : 9-14.

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc15014268

This paper describes an efficient oxime ligation strategy to prepare multivalent conjugates wherein peptides alone or in combination with carbohydrate or oxime groups were coupled to a cyclopeptide scaffold. To demonstrate the versatility of this approach, two classes of conjugates have been prepared. In one class, we attached two or four peptide sequences to the cyclopeptide core together with free oxime groups, while the second class contains an additional substitution with four or two monosaccharides. The well-defined structure of these conjugates was confirmed by high-resolution mass spectrometry.

Citace poskytuje Crossref.org

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$a Daskhan, Gour Chand $u Département de Chimie Moléculaire, UMR CNRS 5250 & ICMG FR 2607, Université Joseph Fourier, BP53, 38041 Grenoble Cedex 9, France.
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$a Garcia, Julian $u Département de Chimie Moléculaire, UMR CNRS 5250 & ICMG FR 2607, Université Joseph Fourier, BP53, 38041 Grenoble Cedex 9, France.
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$a Fiore, Michele $u Département de Chimie Moléculaire, UMR CNRS 5250 & ICMG FR 2607, Université Joseph Fourier, BP53, 38041 Grenoble Cedex 9, France.
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$a Dumy, Pascal $u Département de Chimie Moléculaire, UMR CNRS 5250 & ICMG FR 2607, Université Joseph Fourier, BP53, 38041 Grenoble Cedex 9, France.
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$a Sulc, Miroslav $u Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ-14220 Praha 4, Czech Republic.
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$a Křen, Vladimír $u Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ-14220 Praha 4, Czech Republic. Electronic address: kren@biomed.cas.cz.
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$a Renaudet, Olivier $u Département de Chimie Moléculaire, UMR CNRS 5250 & ICMG FR 2607, Université Joseph Fourier, BP53, 38041 Grenoble Cedex 9, France; Institut Universitaire de France, 103 boulevard Saint-Michel, 75005 Paris, France. Electronic address: olivier.renaudet@ujf-grenoble.fr.
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