• Je něco špatně v tomto záznamu ?

Helicobacter pylori Infection in European children with gastro-duodenal ulcers and erosions

P. Bontems, N. Kalach, J. Vanderpas, B. Iwanczak, T. Casswall, S. Koletzko, G. Oderda, MJ. Martinez-Gomez, P. Urruzuno, A. Kindermann, J. Sykora, G. Veres, E. Roma-Giannikou, E. Pehlivanoglu, F. Megraud, S. Cadranel,

. 2013 ; 32 (12) : 1324-9.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, multicentrická studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc15014499

BACKGROUND: To analyze risk factors associated with gastro-duodenal ulcers and erosions in children. METHODS: Open, prospective, multicenter, case-control study carried out in 11 European countries in patients with gastric or duodenal ulcers/erosions and 2 age-matched controls each. Possible risk factors were recorded. Logistic regression models were performed with adjustment for centers and age groups. RESULTS: Seven-hundred thirty-two patients (244 cases, 153 with erosions only and 91 with ulcers, and 488 controls) were recruited. Children receiving antimicrobials or acid suppressive drugs before endoscopy were excluded (202 cases/390 controls remained for risk factor analysis). Helicobacter pylori was detected more frequently in cases than controls but only in 32.0% versus 20.1% in controls (P = 0.001). Independent exposure factors for gastric ulcers were male gender (P = 0.001), chronic neurologic disease (P = 0.015), chronic renal disease (P < 0.001) and nonsteroidal anti-inflammatory drug consumption (P = 0.035). Exposure factors for duodenal ulcers were H. pylori infection (P < 0.001) and steroid consumption (P = 0.031). Chronic renal disease was the only independent factor associated with gastric erosions (P = 0.026), those associated with duodenal erosions being H. pylori infection (P = 0.023), active smoking (P = 0.006) and chronic arthritis (P = 0.008). No risk factor was identified in 97/202 (48.0%) cases. CONCLUSIONS: H. pylori remains a risk factor for duodenal, but not for gastric lesions in children in countries with low prevalence of infection. No risk factor could be identified in half of the children with gastro-duodenal ulcers/erosions.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc15014499
003      
CZ-PrNML
005      
20150429113649.0
007      
ta
008      
150420s2013 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1097/INF.0000000000000005 $2 doi
035    __
$a (PubMed)24569306
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Bontems, Patrick $u From the *Paediatric Gastroenterology-Hepatology, Queen Fabiola Children's University Hospital, Université Libre de Bruxelles, Brussels, Belgium; †Saint Vincent de Paul Hospital, Clinic of Paediatrics St Antoine, Groupement des Hôpitaux de l'Institut Catholique de Lille (GH-ICL), Lille, France; ‡Medical Microbiology Laboratory, Communicable and Infectious Diseases, Scientific Institute of Public Health, Brussels, Belgium; §Department of Paediatrics, Medical University of Wroclaw, Wroclaw, Poland; ¶Department of Paediatrics, Karolinska University Hospital, Stockholm, Sweden; ‖Dr v. Hauner Children's Hospital, University Medical Center, Munich, Germany; **Department of Paediatrics, University of Piemonte Orientale, Novara, Italy; ††Department of Paediatrics, Hospital Universitario Niño Jesús; ‡‡Department of Paediatrics, Hospital 12 de Octobre, Madrid, Spain; §§Academic Medical Center, Amsterdam, The Netherlands; ¶¶Charles University in Prague, Faculty of Medicine in Pilsen, Department of Paediatrics, Prague, Czech Republic; ‖‖First Department of Paediatrics, Semmelweis University, Budapest, Hungary; ***First Department of Paediatrics of Athens University, Athens, Greece; †††Department of Paediatrics, Marmara University Hospital, Istanbul, Turkey; and ‡‡‡Inserm U853, Victor Segalen Bordeaux 2 University, Bordeaux, France.
245    10
$a Helicobacter pylori Infection in European children with gastro-duodenal ulcers and erosions / $c P. Bontems, N. Kalach, J. Vanderpas, B. Iwanczak, T. Casswall, S. Koletzko, G. Oderda, MJ. Martinez-Gomez, P. Urruzuno, A. Kindermann, J. Sykora, G. Veres, E. Roma-Giannikou, E. Pehlivanoglu, F. Megraud, S. Cadranel,
520    9_
$a BACKGROUND: To analyze risk factors associated with gastro-duodenal ulcers and erosions in children. METHODS: Open, prospective, multicenter, case-control study carried out in 11 European countries in patients with gastric or duodenal ulcers/erosions and 2 age-matched controls each. Possible risk factors were recorded. Logistic regression models were performed with adjustment for centers and age groups. RESULTS: Seven-hundred thirty-two patients (244 cases, 153 with erosions only and 91 with ulcers, and 488 controls) were recruited. Children receiving antimicrobials or acid suppressive drugs before endoscopy were excluded (202 cases/390 controls remained for risk factor analysis). Helicobacter pylori was detected more frequently in cases than controls but only in 32.0% versus 20.1% in controls (P = 0.001). Independent exposure factors for gastric ulcers were male gender (P = 0.001), chronic neurologic disease (P = 0.015), chronic renal disease (P < 0.001) and nonsteroidal anti-inflammatory drug consumption (P = 0.035). Exposure factors for duodenal ulcers were H. pylori infection (P < 0.001) and steroid consumption (P = 0.031). Chronic renal disease was the only independent factor associated with gastric erosions (P = 0.026), those associated with duodenal erosions being H. pylori infection (P = 0.023), active smoking (P = 0.006) and chronic arthritis (P = 0.008). No risk factor was identified in 97/202 (48.0%) cases. CONCLUSIONS: H. pylori remains a risk factor for duodenal, but not for gastric lesions in children in countries with low prevalence of infection. No risk factor could be identified in half of the children with gastro-duodenal ulcers/erosions.
650    _2
$a mladiství $7 D000293
650    _2
$a studie případů a kontrol $7 D016022
650    _2
$a dítě $7 D002648
650    _2
$a předškolní dítě $7 D002675
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a infekce vyvolané Helicobacter pylori $x epidemiologie $x mikrobiologie $x patologie $7 D016481
650    _2
$a Helicobacter pylori $x izolace a purifikace $7 D016480
650    _2
$a lidé $7 D006801
650    _2
$a kojenec $7 D007223
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a peptický vřed $x epidemiologie $x mikrobiologie $7 D010437
650    _2
$a prospektivní studie $7 D011446
650    _2
$a rizikové faktory $7 D012307
651    _2
$a Evropa $x epidemiologie $7 D005060
655    _2
$a časopisecké články $7 D016428
655    _2
$a multicentrická studie $7 D016448
700    1_
$a Kalach, Nicolas
700    1_
$a Vanderpas, Jean
700    1_
$a Iwanczak, Barbara
700    1_
$a Casswall, Thomas
700    1_
$a Koletzko, Sibylle
700    1_
$a Oderda, Giuseppina
700    1_
$a Martinez-Gomez, Maria José
700    1_
$a Urruzuno, Pedro
700    1_
$a Kindermann, Angelika
700    1_
$a Sykora, Josef
700    1_
$a Veres, Gabor
700    1_
$a Roma-Giannikou, Eleftheria
700    1_
$a Pehlivanoglu, Ender
700    1_
$a Megraud, Francis
700    1_
$a Cadranel, Samy
773    0_
$w MED00003732 $t The Pediatric infectious disease journal $x 1532-0987 $g Roč. 32, č. 12 (2013), s. 1324-9
856    41
$u https://pubmed.ncbi.nlm.nih.gov/24569306 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20150420 $b ABA008
991    __
$a 20150429113953 $b ABA008
999    __
$a ok $b bmc $g 1072080 $s 897377
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2013 $b 32 $c 12 $d 1324-9 $i 1532-0987 $m The Pediatric infectious disease journal $n Pediatr Infect Dis J $x MED00003732
LZP    __
$a Pubmed-20150420

Najít záznam

Citační ukazatele

Možnosti archivace