-
Je něco špatně v tomto záznamu ?
In Vitro Antistaphylococcal Effects of Embelia schimperi Extracts and Their Component Embelin with Oxacillin and Tetracycline
J. Rondevaldova, O. Leuner, A. Teka, E. Lulekal, J. Havlik, P. Van Damme, L. Kokoska,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Hindawi Publishing Open Access od 2004-01-01
PubMed Central od 2004
Europe PubMed Central od 2004
ProQuest Central od 2011-01-01
Open Access Digital Library od 2004-01-01
Open Access Digital Library od 2004-01-01
Open Access Digital Library od 2004-01-01
CINAHL Plus with Full Text (EBSCOhost) od 2008-03-01
Nursing & Allied Health Database (ProQuest) od 2011-01-01
Health & Medicine (ProQuest) od 2011-01-01
Psychology Database (ProQuest) od 2011-01-01
Odkazy
PubMed
25802535
DOI
10.1155/2015/175983
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
Bacterial infections are in less-developed countries traditionally treated by remedies prepared from medicinal plants. Embelia schimperi (Vatke) is a plant used as a taenicide or disinfectant in Ethiopia, very often taken mixed with another plant species. In the present study, we examined two extracts prepared from seeds and twigs with leaves of E. schimperi and its main present secondary metabolite embelin for their antibacterial combinatory effect with oxacillin and tetracycline against sensitive and resistant Staphylococcus aureus strains. Minimum inhibitory concentrations were determined through the broth microdilution method, whereas the combinatory effect was evaluated through fractional inhibitory concentration sum (ΣFIC) indices. Results show many positive interactions and synergy occurring in embelin and oxacillin combinations against 4 out of 9 strains (ΣFIC 0.203-0.477) and for embelin and tetracycline combination against 3 out of 9 strains (ΣFIC 0.400-0.496). Moreover, the resistance to oxacillin has been overcome in 2 strains and to tetracycline in 3 strains. According to our knowledge, this is the first study showing antimicrobial combinatory effect of E. schimperi as well as of embelin. These findings can be used for the further research targeted on the development of new antistaphylococcal agents.
- 000
- 00000naa a2200000 a 4500
- 001
- bmc15014643
- 003
- CZ-PrNML
- 005
- 20150427102014.0
- 007
- ta
- 008
- 150420s2015 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1155/2015/175983 $2 doi
- 035 __
- $a (PubMed)25802535
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Rondevaldova, Johana $u Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague, Kamycka 129, Suchdol, 165 21 Prague 6, Czech Republic.
- 245 10
- $a In Vitro Antistaphylococcal Effects of Embelia schimperi Extracts and Their Component Embelin with Oxacillin and Tetracycline / $c J. Rondevaldova, O. Leuner, A. Teka, E. Lulekal, J. Havlik, P. Van Damme, L. Kokoska,
- 520 9_
- $a Bacterial infections are in less-developed countries traditionally treated by remedies prepared from medicinal plants. Embelia schimperi (Vatke) is a plant used as a taenicide or disinfectant in Ethiopia, very often taken mixed with another plant species. In the present study, we examined two extracts prepared from seeds and twigs with leaves of E. schimperi and its main present secondary metabolite embelin for their antibacterial combinatory effect with oxacillin and tetracycline against sensitive and resistant Staphylococcus aureus strains. Minimum inhibitory concentrations were determined through the broth microdilution method, whereas the combinatory effect was evaluated through fractional inhibitory concentration sum (ΣFIC) indices. Results show many positive interactions and synergy occurring in embelin and oxacillin combinations against 4 out of 9 strains (ΣFIC 0.203-0.477) and for embelin and tetracycline combination against 3 out of 9 strains (ΣFIC 0.400-0.496). Moreover, the resistance to oxacillin has been overcome in 2 strains and to tetracycline in 3 strains. According to our knowledge, this is the first study showing antimicrobial combinatory effect of E. schimperi as well as of embelin. These findings can be used for the further research targeted on the development of new antistaphylococcal agents.
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Leuner, Olga $u Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague, Kamycka 129, Suchdol, 165 21 Prague 6, Czech Republic.
- 700 1_
- $a Teka, Alemtshay $u Laboratory for Tropical and Subtropical Agriculture and Ethnobotany, Department of Plant Production, Faculty of Bio-Science Engineering, Ghent University, Coupure links 653, 9000 Ghent, Belgium ; Department of Plant Biology and Biodiversity Management, College of Natural Sciences, Addis Ababa University, P.O. Box 3434, Addis Ababa, Ethiopia.
- 700 1_
- $a Lulekal, Ermias $u Department of Biology, College of Natural Sciences, 445 Debre Berhan University, Debre Berhan, Ethiopia.
- 700 1_
- $a Havlik, Jaroslav $u Department of Microbiology, Nutrition and Dietetics, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamycka 129, Suchdol, 165 21 Prague 6, Czech Republic.
- 700 1_
- $a Van Damme, Patrick $u Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague, Kamycka 129, Suchdol, 165 21 Prague 6, Czech Republic ; Laboratory for Tropical and Subtropical Agriculture and Ethnobotany, Department of Plant Production, Faculty of Bio-Science Engineering, Ghent University, Coupure links 653, 9000 Ghent, Belgium.
- 700 1_
- $a Kokoska, Ladislav $u Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague, Kamycka 129, Suchdol, 165 21 Prague 6, Czech Republic.
- 773 0_
- $w MED00174367 $t Evidence-based complementary and alternative medicine eCAM $x 1741-427X $g Roč. 2015, č. - (2015), s. 175983
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/25802535 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20150420 $b ABA008
- 991 __
- $a 20150427102318 $b ABA008
- 999 __
- $a ind $b bmc $g 1072224 $s 897521
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2015 $b 2015 $c - $d 175983 $i 1741-427X $m Evidence-based complementary and alternative medicine $n Evid Based Complement Alternat Med $x MED00174367
- LZP __
- $a Pubmed-20150420