-
Something wrong with this record ?
Evaluation of tributyltin toxicity in Chinese rare minnow larvae by abnormal behavior, energy metabolism and endoplasmic reticulum stress
ZH. Li, P. Li,
Language English Country Ireland
Document type Journal Article, Research Support, Non-U.S. Gov't
Links
PubMed
25499138
DOI
10.1016/j.cbi.2014.12.010
Knihovny.cz E-resources
- MeSH
- Behavior, Animal drug effects MeSH
- Cyprinidae growth & development MeSH
- DNA-Binding Proteins genetics metabolism MeSH
- Endoribonucleases genetics metabolism MeSH
- Energy Metabolism drug effects MeSH
- eIF-2 Kinase genetics metabolism MeSH
- Larva drug effects metabolism MeSH
- Endoplasmic Reticulum Stress drug effects MeSH
- Activating Transcription Factor 4 genetics metabolism MeSH
- Transcription Factors genetics metabolism MeSH
- Trialkyltin Compounds toxicity MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- China MeSH
Tributyltin (TBT) is a ubiquitous contaminant in aquatic environment, but the detailed mechanisms underlying the toxicity of TBT have not been fully understood. In this study, the effects of TBT on behavior, energy metabolism and endoplasmic reticulum (ER) stress were investigated by using Chinese rare minnow larvae. Fish larvae were exposed at sublethal concentrations of TBT (100, 400 and 800 ng/L) for 7 days. Compared with the control, energy metabolic parameters (RNA/DNA ratio, Na(+)-K(+)-ATPase) were significantly inhibited in fish exposed at highest concentration (800 ng/L), as well as abnormal behaviors observed. Moreover, we found that the PERK (PKR-like ER kinase)-eIF2α (eukaryotic translation initiation factor 2α) pathway, as the main branch was activated by TBT exposure in fish larvae. In short, TBT-induced physiological, biochemical and molecular responses in fish larvae were reflected in parameters measured in this study, which suggest that these biomarkers could be used as potential indicators for monitoring organotin compounds present in aquatic environment.
- 000
- 00000naa a2200000 a 4500
- 001
- bmc15022903
- 003
- CZ-PrNML
- 005
- 20201113095956.0
- 007
- ta
- 008
- 150709s2015 ie f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.cbi.2014.12.010 $2 doi
- 035 __
- $a (PubMed)25499138
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ie
- 100 1_
- $a Li, Zhi-Hua $u Key Laboratory of Freshwater Biodiversity Conservation (Ministry of Agriculture), Key Field Station for Fishery Resource and Environment in Upper-Middle Reaches of Yangtze River (Ministry of Agriculture), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China; University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Research Institute of Fish Culture and Hydrobiology, Zátiší 728/II, 389 25 Vodňany, Czech Republic. Electronic address: zhihuali06@yahoo.com.
- 245 10
- $a Evaluation of tributyltin toxicity in Chinese rare minnow larvae by abnormal behavior, energy metabolism and endoplasmic reticulum stress / $c ZH. Li, P. Li,
- 520 9_
- $a Tributyltin (TBT) is a ubiquitous contaminant in aquatic environment, but the detailed mechanisms underlying the toxicity of TBT have not been fully understood. In this study, the effects of TBT on behavior, energy metabolism and endoplasmic reticulum (ER) stress were investigated by using Chinese rare minnow larvae. Fish larvae were exposed at sublethal concentrations of TBT (100, 400 and 800 ng/L) for 7 days. Compared with the control, energy metabolic parameters (RNA/DNA ratio, Na(+)-K(+)-ATPase) were significantly inhibited in fish exposed at highest concentration (800 ng/L), as well as abnormal behaviors observed. Moreover, we found that the PERK (PKR-like ER kinase)-eIF2α (eukaryotic translation initiation factor 2α) pathway, as the main branch was activated by TBT exposure in fish larvae. In short, TBT-induced physiological, biochemical and molecular responses in fish larvae were reflected in parameters measured in this study, which suggest that these biomarkers could be used as potential indicators for monitoring organotin compounds present in aquatic environment.
- 650 _2
- $a transkripční faktor ATF4 $x genetika $x metabolismus $7 D051701
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a chování zvířat $x účinky léků $7 D001522
- 650 _2
- $a Cyprinidae $x růst a vývoj $7 D003530
- 650 _2
- $a DNA vazebné proteiny $x genetika $x metabolismus $7 D004268
- 650 _2
- $a stres endoplazmatického retikula $x účinky léků $7 D059865
- 650 _2
- $a endoribonukleasy $x genetika $x metabolismus $7 D004722
- 650 _2
- $a energetický metabolismus $x účinky léků $7 D004734
- 650 _2
- $a larva $x účinky léků $x metabolismus $7 D007814
- 650 _2
- $a transkripční faktory $x genetika $x metabolismus $7 D014157
- 650 _2
- $a trialkylcínové sloučeniny $x toxicita $7 D014220
- 650 _2
- $a kinasa eIF-2 $x genetika $x metabolismus $7 D019892
- 651 _2
- $a Čína $7 D002681
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Li, Ping, $d 1980- $u Key Laboratory of Freshwater Biodiversity Conservation (Ministry of Agriculture), Key Field Station for Fishery Resource and Environment in Upper-Middle Reaches of Yangtze River (Ministry of Agriculture), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China; University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Research Institute of Fish Culture and Hydrobiology, Zátiší 728/II, 389 25 Vodňany, Czech Republic. $7 jcu2011664650
- 773 0_
- $w MED00002111 $t Chemico-biological interactions $x 1872-7786 $g Roč. 227, č. - (2015), s. 32-6
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/25499138 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20150709 $b ABA008
- 991 __
- $a 20201113095954 $b ABA008
- 999 __
- $a ok $b bmc $g 1083242 $s 905896
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2015 $b 227 $c - $d 32-6 $i 1872-7786 $m Chemico-biological interactions $n Chem Biol Interact $x MED00002111
- LZP __
- $a Pubmed-20150709