Evaluation of tributyltin toxicity in Chinese rare minnow larvae by abnormal behavior, energy metabolism and endoplasmic reticulum stress
Jazyk angličtina Země Irsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25499138
DOI
10.1016/j.cbi.2014.12.010
PII: S0009-2797(14)00388-3
Knihovny.cz E-zdroje
- Klíčová slova
- Behavior, Endoplasmic reticulum stress, Energy metabolism, Fish, Tributyltin,
- MeSH
- chování zvířat účinky léků MeSH
- Cyprinidae růst a vývoj MeSH
- DNA vazebné proteiny genetika metabolismus MeSH
- endoribonukleasy genetika metabolismus MeSH
- energetický metabolismus účinky léků MeSH
- kinasa eIF-2 genetika metabolismus MeSH
- larva účinky léků metabolismus MeSH
- stres endoplazmatického retikula účinky léků MeSH
- transkripční faktor ATF4 genetika metabolismus MeSH
- transkripční faktory RFX MeSH
- transkripční faktory genetika metabolismus MeSH
- trialkylcínové sloučeniny toxicita MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Čína MeSH
- Názvy látek
- DNA vazebné proteiny MeSH
- endoribonukleasy MeSH
- kinasa eIF-2 MeSH
- transkripční faktor ATF4 MeSH
- transkripční faktory RFX MeSH
- transkripční faktory MeSH
- trialkylcínové sloučeniny MeSH
- tributyltin MeSH Prohlížeč
Tributyltin (TBT) is a ubiquitous contaminant in aquatic environment, but the detailed mechanisms underlying the toxicity of TBT have not been fully understood. In this study, the effects of TBT on behavior, energy metabolism and endoplasmic reticulum (ER) stress were investigated by using Chinese rare minnow larvae. Fish larvae were exposed at sublethal concentrations of TBT (100, 400 and 800 ng/L) for 7 days. Compared with the control, energy metabolic parameters (RNA/DNA ratio, Na(+)-K(+)-ATPase) were significantly inhibited in fish exposed at highest concentration (800 ng/L), as well as abnormal behaviors observed. Moreover, we found that the PERK (PKR-like ER kinase)-eIF2α (eukaryotic translation initiation factor 2α) pathway, as the main branch was activated by TBT exposure in fish larvae. In short, TBT-induced physiological, biochemical and molecular responses in fish larvae were reflected in parameters measured in this study, which suggest that these biomarkers could be used as potential indicators for monitoring organotin compounds present in aquatic environment.