Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Healthy lung tissue response to mechanical ventilation in an experimental porcine model

J. Fremuth, J. Kobr, K. Pizingerova, L. Sasek, P. Jehlicka, J. Zamboryova, O. Hess, J. Vrzalova, J. Racek, Z. Tonar,

. 2014 ; 28 (5) : 803-9.

Jazyk angličtina Země Řecko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc15023054

BACKGROUND: The aim of this comparative study was to assess the impact of two different settings of tidal volume (Vt) on the function and morphology of the mechanically ventilated lungs during a 12-h period. MATERIALS AND METHODS: A total of 32 animals were randomly divided into two groups. Group A included piglets ventilated with a Vt of 6 ml/kg and group B piglets ventilated with a Vt of 10 ml/kg. Lung functions and pulmonary mechanics were evaluated after 1 and 12 h of mechanical ventilation. Morphological changes of the lung tissue were evaluated at the end of the study. RESULTS: Twelve hours of lower Vt ventilation was associated with the development of respiratory acidosis but minimal histological changes. Higher Vt led to pronounced histological changes in terms of proliferation and apoptosis and a decrease of dynamic compliance, with a trend towards lower oxygenation during the study. CONCLUSION: Mechanical ventilation with a Vt of 6 ml/kg induces minimal histological lung parenchymal changes in terms of proliferation and apoptosis. Positive pressure mechanical ventilation with Vt of 10 ml/kg does not protect lung tissue and induces substantial proliferative and apoptotic changes within the lung parenchyma. Positive pressure mechanical ventilation with Vt of 10 ml/kg does not guarantee protection of healthy pulmonary tissue in the absence of a priming pulmonary insult.

000      
00000naa a2200000 a 4500
001      
bmc15023054
003      
CZ-PrNML
005      
20201102123204.0
007      
ta
008      
150709s2014 gr f 000 0|eng||
009      
AR
035    __
$a (PubMed)25189892
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gr
100    1_
$a Fremuth, Jiří $7 xx0218461 $u Pediatric intensive care unit (PICU), Department of Pediatrics, Faculty of Medicine, Charles University of Prague in Pilsen, Pilsen, Czech Republic fremuthj@gmail.com.
245    10
$a Healthy lung tissue response to mechanical ventilation in an experimental porcine model / $c J. Fremuth, J. Kobr, K. Pizingerova, L. Sasek, P. Jehlicka, J. Zamboryova, O. Hess, J. Vrzalova, J. Racek, Z. Tonar,
520    9_
$a BACKGROUND: The aim of this comparative study was to assess the impact of two different settings of tidal volume (Vt) on the function and morphology of the mechanically ventilated lungs during a 12-h period. MATERIALS AND METHODS: A total of 32 animals were randomly divided into two groups. Group A included piglets ventilated with a Vt of 6 ml/kg and group B piglets ventilated with a Vt of 10 ml/kg. Lung functions and pulmonary mechanics were evaluated after 1 and 12 h of mechanical ventilation. Morphological changes of the lung tissue were evaluated at the end of the study. RESULTS: Twelve hours of lower Vt ventilation was associated with the development of respiratory acidosis but minimal histological changes. Higher Vt led to pronounced histological changes in terms of proliferation and apoptosis and a decrease of dynamic compliance, with a trend towards lower oxygenation during the study. CONCLUSION: Mechanical ventilation with a Vt of 6 ml/kg induces minimal histological lung parenchymal changes in terms of proliferation and apoptosis. Positive pressure mechanical ventilation with Vt of 10 ml/kg does not protect lung tissue and induces substantial proliferative and apoptotic changes within the lung parenchyma. Positive pressure mechanical ventilation with Vt of 10 ml/kg does not guarantee protection of healthy pulmonary tissue in the absence of a priming pulmonary insult.
650    _2
$a zvířata $7 D000818
650    _2
$a apoptóza $7 D017209
650    _2
$a kaspasa 3 $x metabolismus $7 D053148
650    _2
$a proliferace buněk $7 D049109
650    _2
$a imunohistochemie $7 D007150
650    _2
$a antigen Ki-67 $x metabolismus $7 D019394
650    _2
$a plíce $x metabolismus $x patologie $x patofyziologie $7 D008168
650    _2
$a modely u zvířat $7 D023421
650    12
$a umělé dýchání $x škodlivé účinky $7 D012121
650    _2
$a respirační funkční testy $7 D012129
650    _2
$a prasata $7 D013552
650    _2
$a dechový objem $7 D013990
650    _2
$a časové faktory $7 D013997
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Kobr, Jiri $u Pediatric intensive care unit (PICU), Department of Pediatrics, Faculty of Medicine, Charles University of Prague in Pilsen, Pilsen, Czech Republic.
700    1_
$a Pizingerova, Katerina $u Pediatric intensive care unit (PICU), Department of Pediatrics, Faculty of Medicine, Charles University of Prague in Pilsen, Pilsen, Czech Republic.
700    1_
$a Sasek, Lumir $u Pediatric intensive care unit (PICU), Department of Pediatrics, Faculty of Medicine, Charles University of Prague in Pilsen, Pilsen, Czech Republic.
700    1_
$a Jehlicka, Petr $u Pediatric intensive care unit (PICU), Department of Pediatrics, Faculty of Medicine, Charles University of Prague in Pilsen, Pilsen, Czech Republic.
700    1_
$a Zamboryová, Jana $u Pediatric intensive care unit (PICU), Department of Pediatrics, Faculty of Medicine, Charles University of Prague in Pilsen, Pilsen, Czech Republic. $7 xx0224590
700    1_
$a Hes, Ondřej, $d 1968- $7 jn20001103502 $u Šikl Institute of Pathological Anatomy, Faculty of Medicine, Charles University of Prague in Pilsen, Pilsen, Czech Republic.
700    1_
$a Vrzalova, Jana $u Central Laboratory of Immunoanalysis, Faculty of Medicine, Charles University of Prague in Pilsen, Pilsen, Czech Republic.
700    1_
$a Racek, Jaroslav $u Department of Clinical Biochemistry and Hematology, Faculty of Medicine, Charles University of Prague in Pilsen, Pilsen, Czech Republic.
700    1_
$a Tonar, Zbynek $u Department of Histology and Embryology, Faculty of Medicine, Charles University of Prague in Pilsen, Pilsen, Czech Republic Biomedical Centre, Faculty of Medicine, Charles University of Prague in Pilsen, Pilsen, Czech Republic.
773    0_
$w MED00175831 $t In vivo (Athens, Greece) $x 1791-7549 $g Roč. 28, č. 5 (2014), s. 803-9
856    41
$u https://pubmed.ncbi.nlm.nih.gov/25189892 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20150709 $b ABA008
991    __
$a 20201102123136 $b ABA008
999    __
$a ok $b bmc $g 1083393 $s 906047
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 28 $c 5 $d 803-9 $i 1791-7549 $m In Vivo $n In Vivo $x MED00175831
LZP    __
$a Pubmed-20150709

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace