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Transmission potential of antimony-resistant leishmania field isolates

V. Seblova, B. Oury, N. Eddaikra, K. Aït-Oudhia, F. Pratlong, E. Gazanion, C. Maia, P. Volf, D. Sereno,

. 2014 ; 58 (10) : 6273-6.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc15023230

E-zdroje NLK Online Plný text

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Odkazy
PubMed 25049256
DOI 10.1128/aac.02406-13
Knihovny.cz E-zdroje

We studied the development of antimony-resistant Leishmania infantum in natural vectors Lutzomyia longipalpis and Phlebotomus perniciosus to ascertain the risk of parasite transmission by sand flies. All three resistant strains produced fully mature late-stage infections in sand flies; moreover, the resistant phenotype was maintained after the passage through the vector. These results highlight the risk of circulation of resistant Leishmania strains and question the use of human drugs for treatment of dogs as Leishmania reservoirs.

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