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Different effects of lobeline on neuronal and muscle nicotinic receptors
M. Kaniakova, K. Skrenkova, S. Adamek, F. Vyskocil, J. Krusek,
Language English Country Netherlands
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Chlorocebus aethiops MeSH
- COS Cells MeSH
- Rats MeSH
- Humans MeSH
- Lobeline pharmacology MeSH
- Neurons drug effects metabolism MeSH
- Receptors, Nicotinic metabolism MeSH
- Nicotinic Agonists pharmacology MeSH
- Organ Specificity MeSH
- Muscles drug effects metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Lobeline is a plant alkaloid known to interact with cholinergic system. The effect of lobeline on neuronal α3β4 receptors expressed in COS cells and muscle embryonic αβγδ receptors naturally expressed in TE671 cells was studied using a patch-clamp technique. Our results show that lobeline inhibited responses to acetylcholine in human embryonic muscle nicotinic receptor in a pseudo-noncompetitive manner. The responses of rat neuronal α3β4 receptors to a low concentration of acetylcholine were potentiated by a mixed occupation mechanism that corresponds to "competitive potentiation". This potentiation turned into voltage-dependent inhibition for α3β4 receptors was activated by a high concentration of acetylcholine.
References provided by Crossref.org
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