• Je něco špatně v tomto záznamu ?

Different effects of lobeline on neuronal and muscle nicotinic receptors

M. Kaniakova, K. Skrenkova, S. Adamek, F. Vyskocil, J. Krusek,

. 2014 ; 738 (-) : 352-9.

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc15023331

Lobeline is a plant alkaloid known to interact with cholinergic system. The effect of lobeline on neuronal α3β4 receptors expressed in COS cells and muscle embryonic αβγδ receptors naturally expressed in TE671 cells was studied using a patch-clamp technique. Our results show that lobeline inhibited responses to acetylcholine in human embryonic muscle nicotinic receptor in a pseudo-noncompetitive manner. The responses of rat neuronal α3β4 receptors to a low concentration of acetylcholine were potentiated by a mixed occupation mechanism that corresponds to "competitive potentiation". This potentiation turned into voltage-dependent inhibition for α3β4 receptors was activated by a high concentration of acetylcholine.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc15023331
003      
CZ-PrNML
005      
20171209133333.0
007      
ta
008      
150709s2014 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.ejphar.2014.05.057 $2 doi
035    __
$a (PubMed)24929055
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Kaniakova, Martina $u Institute of Physiology, Academy of Sciences of the Czech Republic, v.v.i., Vídeňská 1083, 142 20 Prague 4, Czech Republic.
245    10
$a Different effects of lobeline on neuronal and muscle nicotinic receptors / $c M. Kaniakova, K. Skrenkova, S. Adamek, F. Vyskocil, J. Krusek,
520    9_
$a Lobeline is a plant alkaloid known to interact with cholinergic system. The effect of lobeline on neuronal α3β4 receptors expressed in COS cells and muscle embryonic αβγδ receptors naturally expressed in TE671 cells was studied using a patch-clamp technique. Our results show that lobeline inhibited responses to acetylcholine in human embryonic muscle nicotinic receptor in a pseudo-noncompetitive manner. The responses of rat neuronal α3β4 receptors to a low concentration of acetylcholine were potentiated by a mixed occupation mechanism that corresponds to "competitive potentiation". This potentiation turned into voltage-dependent inhibition for α3β4 receptors was activated by a high concentration of acetylcholine.
650    _2
$a zvířata $7 D000818
650    _2
$a COS buňky $7 D019556
650    _2
$a Cercopithecus aethiops $7 D002522
650    _2
$a lidé $7 D006801
650    _2
$a lobelin $x farmakologie $7 D008120
650    _2
$a svaly $x účinky léků $x metabolismus $7 D009132
650    _2
$a neurony $x účinky léků $x metabolismus $7 D009474
650    _2
$a nikotinoví agonisté $x farmakologie $7 D018722
650    _2
$a orgánová specificita $7 D009928
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a nikotinové receptory $x metabolismus $7 D011978
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Skrenkova, Kristyna $u Institute of Physiology, Academy of Sciences of the Czech Republic, v.v.i., Vídeňská 1083, 142 20 Prague 4, Czech Republic; Department of Physiology, Faculty of Science, Charles University, Viničná 7, 120 00 Prague, Czech Republic.
700    1_
$a Adámek, Svatopluk $u Third Surgical Department, First Faculty of Medicine, Charles University, V Úvalu 84, 150 06 Prague, Czech Republic. $7 mzk2007363535 $4
700    1_
$a Vyskocil, Frantisek $u Institute of Physiology, Academy of Sciences of the Czech Republic, v.v.i., Vídeňská 1083, 142 20 Prague 4, Czech Republic; Department of Physiology, Faculty of Science, Charles University, Viničná 7, 120 00 Prague, Czech Republic.
700    1_
$a Krusek, Jan $u Institute of Physiology, Academy of Sciences of the Czech Republic, v.v.i., Vídeňská 1083, 142 20 Prague 4, Czech Republic. Electronic address: krusek@biomed.cas.cz.
773    0_
$w MED00001641 $t European journal of pharmacology $x 1879-0712 $g Roč. 738, č. - (2014), s. 352-9
856    41
$u https://pubmed.ncbi.nlm.nih.gov/24929055 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20150709 $b ABA008
991    __
$a 20150730105625 $b ABA008
999    __
$a ok $b bmc $g 1083669 $s 906324
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 738 $c - $d 352-9 $i 1879-0712 $m European journal of pharmacology $n Eur J Pharmacol $x MED00001641
LZP    __
$a Pubmed-20150709

Najít záznam

Citační ukazatele

Možnosti archivace