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Solid-phase synthesis of trisubstituted 2,5-dihydrobenzo[f][1,2,5]thiadiazepine 1,1-dioxide derivatives
V. Fülöpová, V. Krchňák,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24884092
DOI
10.1021/co500084k
Knihovny.cz E-resources
- MeSH
- Amino Acids chemistry MeSH
- Benzene Derivatives chemical synthesis chemistry MeSH
- Chlorides chemistry MeSH
- Cyclization MeSH
- Fluorenes chemistry MeSH
- Halogenation MeSH
- Ketones chemistry MeSH
- Nitrobenzenes chemistry MeSH
- Oxides chemical synthesis chemistry MeSH
- Solid-Phase Synthesis Techniques methods MeSH
- Thiazepines chemical synthesis chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The solid-phase synthesis of trisubstituted 2,5-dihydrobenzo[f][1,2,5]thiadiazepine 1,1-dioxides is reported. Acyclic polymer-supported intermediates were prepared using commercially available building blocks: Fmoc-protected amino acids, 2-nitrobenzenesulfonyl chlorides, and bromoketones. The acyclic precursors underwent acid-mediated release from the resin and the cyclization was completed in solution.
References provided by Crossref.org
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- $a Fülöpová, Veronika $u Department of Organic Chemistry, Institute of Molecular and Translational Medicine, Faculty of Science, Palacky University , 17. Listopadu 12, 771 46 Olomouc, Czech Republic.
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