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Implications of differential age distribution of disease-associated meningococcal lineages for vaccine development
C. Brehony, CL. Trotter, ME. Ramsay, M. Chandra, KA. Jolley, A. van der Ende, F. Carion, L. Berthelsen, S. Hoffmann, H. Harðardóttir, JA. Vazquez, K. Murphy, M. Toropainen, M. Caniça, E. Ferreira, M. Diggle, GF. Edwards, MK. Taha, P. Stefanelli,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed Central od 2006 do 2017
Europe PubMed Central od 2006 do 2017
Open Access Digital Library od 1994-01-01
Odkazy
PubMed
24695776
DOI
10.1128/cvi.00133-14
Knihovny.cz E-zdroje
- MeSH
- antigeny bakteriální imunologie MeSH
- bakteriální pouzdra imunologie MeSH
- dítě MeSH
- dospělí MeSH
- kojenec MeSH
- lidé MeSH
- meningokoková meningitida imunologie mikrobiologie prevence a kontrola MeSH
- meningokokové vakcíny imunologie MeSH
- mladiství MeSH
- mladý dospělý MeSH
- multilokusová sekvenční typizace MeSH
- Neisseria meningitidis séroskupiny B imunologie MeSH
- Neisseria meningitidis imunologie izolace a purifikace MeSH
- předškolní dítě MeSH
- sekvence nukleotidů MeSH
- sekvenční analýza DNA MeSH
- věkové rozložení MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- předškolní dítě MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
New vaccines targeting meningococci expressing serogroup B polysaccharide have been developed, with some being licensed in Europe. Coverage depends on the distribution of disease-associated genotypes, which may vary by age. It is well established that a small number of hyperinvasive lineages account for most disease, and these lineages are associated with particular antigens, including vaccine candidates. A collection of 4,048 representative meningococcal disease isolates from 18 European countries, collected over a 3-year period, were characterized by multilocus sequence typing (MLST). Age data were available for 3,147 isolates. The proportions of hyperinvasive lineages, identified as particular clonal complexes (ccs) by MLST, differed among age groups. Subjects <1 year of age experienced lower risk of sequence type 11 (ST-11) cc, ST-32 cc, and ST-269 cc disease and higher risk of disease due to unassigned STs, 1- to 4-year-olds experienced lower risk of ST-11 cc and ST-32 cc disease, 5- to 14-year-olds were less likely to experience ST-11 cc and ST-269 cc disease, and ≥25-year-olds were more likely to experience disease due to less common ccs and unassigned STs. Younger and older subjects were vulnerable to a more diverse set of genotypes, indicating the more clonal nature of genotypes affecting adolescents and young adults. Knowledge of temporal and spatial diversity and the dynamics of meningococcal populations is essential for disease control by vaccines, as coverage is lineage specific. The nonrandom age distribution of hyperinvasive lineages has consequences for the design and implementation of vaccines, as different variants, or perhaps targets, may be required for different age groups.
Department of Bacteriology and Immunology Norwegian Institute of Public Health Oslo Norway
Department of Microbiology Landspitali University Hospital Reykjavik Iceland
Department of Veterinary Medicine University of Cambridge Cambridge United Kingdom
Department of Zoology University of Oxford Oxford United Kingdom
Institut für Hygiene und Mikrobiologie Würzburg Germany
Irish Meningococcal and Meningitis Reference Laboratory Dublin Ireland
Meningococcal Reference Laboratory Madrid Spain
Meningococcal Reference Laboratory Scientific Institute of Public Health Brussels Belgium
Meningococcal Reference Unit Manchester Royal Infirmary Manchester United Kingdom
National Institute for Health and Welfare Helsinki Finland
National Meningococcal Reference Laboratory National School of Public Health Athens Greece
National Reference Centre for Meningococci Pasteur Institute Paris France
Neisseria and Streptococcus Reference Laboratory Statens Serum Institut Copenhagen Denmark
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