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Ixodes ricinus salivary serpin IRS-2 affects Th17 differentiation via inhibition of the interleukin-6/STAT-3 signaling pathway
J. Páleníková, J. Lieskovská, H. Langhansová, M. Kotsyfakis, J. Chmelař, J. Kopecký,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Free Medical Journals
od 1970 do Před 6 měsíci
Freely Accessible Science Journals
od 1995 do Před 6 měsíci
PubMed Central
od 1970 do Před 6 měsíci
Europe PubMed Central
od 1970 do Před 6 měsíci
Open Access Digital Library
od 1970-01-01
Open Access Digital Library
od 1970-01-01
PubMed
25712932
DOI
10.1128/iai.03065-14
Knihovny.cz E-zdroje
- MeSH
- Borrelia imunologie MeSH
- buněčná diferenciace účinky léků MeSH
- buňky Th17 účinky léků fyziologie MeSH
- dendritické buňky účinky léků fyziologie MeSH
- interleukin-6 antagonisté a inhibitory metabolismus MeSH
- klíště MeSH
- myši inbrední C57BL MeSH
- serpiny metabolismus MeSH
- signální transdukce účinky léků MeSH
- transkripční faktor STAT3 antagonisté a inhibitory metabolismus MeSH
- zvířata MeSH
- Check Tag
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Th17 cells constitute a subset of CD4(+) T lymphocytes that play a crucial role in protection against extracellular bacteria and fungi. They are also associated with tissue injury in autoimmune and inflammatory diseases. Here, we report that serpin from the tick Ixodes ricinus, IRS-2, inhibits Th17 differentiation by impairment of the interleukin-6 (IL-6)/STAT-3 signaling pathway. Following activation, mature dendritic cells produce an array of cytokines, including the pleiotropic cytokine IL-6, which triggers the IL-6 signaling pathway. The major transcription factor activated by IL-6 is STAT-3. We show that IRS-2 selectively inhibits production of IL-6 in dendritic cells stimulated with Borrelia spirochetes, which leads to attenuated STAT-3 phosphorylation and finally to impaired Th17 differentiation. The results presented extend the knowledge about the effect of tick salivary serpins on innate immunity cells and their function in driving adaptive immune responses.
Citace poskytuje Crossref.org
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