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The effect of different doses of atropine on gastric myoelectrical activity in fasting experimental pigs

Jan Bures, Jaroslav Kvetina, Ilja Tacheci, Michal Pavlik, Martin Kunes, Stanislav Rejchrt, Kamil Kuca, Marcela Kopacova

. 2015 ; 13 (4) : 273-277.

Jazyk angličtina Země Česko

Typ dokumentu práce podpořená grantem, pragmatická klinická studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc15040349

Grantová podpora
NT14270 MZ0 CEP - Centrální evidence projektů

Electrogastrography (EGG) is a non-invasive method for the assessment of gastric myoelectrical activity. Porcine EGG is comparable with human one. There are no data on the impact of moderate to high doses of atropine on EGG, neither in humans nor experimental pigs. The purpose of this study was to evaluate the effect of different doses of atropine on EGG in experimental pigs. Six fasting pigs entered the study three times in a random order. The baseline EGG recording lasted 20 min, followed by a 105-min EGG trial recording. Intramuscular atropine 1.5 mg (part 1), 3.0 mg (part 2) and 4.5 mg (part 3) was administrated after the baseline EGG. Atropine doses of 1.5 and 3.0 mg revealed a similar pattern in the EGG power course. After an initial increase (at the first 15-min interval), the areas of amplitudes decreased back to values comparable with basal levels and subsequently increased significantly again to the maximum at 105 min. The EGG power was quite different after the administration of 4.5 mg of atropine. Areas of amplitudes decreased gradually to the minimum values at 105 min after atropine administration. In conclusion, different dose-dependent changes in the EGG pattern were found after moderate to high doses of atropine.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

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$a Bureš, Jan, $d 1954- $7 nlk19990073060 $u Second Department of Internal Medicine – Gastroenterology, Charles University in Praha, Faculty of Medicine at Hradec Kralove, University Teaching Hospital, Hradec Kralove, Czech Republic
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$a The effect of different doses of atropine on gastric myoelectrical activity in fasting experimental pigs / $c Jan Bures, Jaroslav Kvetina, Ilja Tacheci, Michal Pavlik, Martin Kunes, Stanislav Rejchrt, Kamil Kuca, Marcela Kopacova
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$a Electrogastrography (EGG) is a non-invasive method for the assessment of gastric myoelectrical activity. Porcine EGG is comparable with human one. There are no data on the impact of moderate to high doses of atropine on EGG, neither in humans nor experimental pigs. The purpose of this study was to evaluate the effect of different doses of atropine on EGG in experimental pigs. Six fasting pigs entered the study three times in a random order. The baseline EGG recording lasted 20 min, followed by a 105-min EGG trial recording. Intramuscular atropine 1.5 mg (part 1), 3.0 mg (part 2) and 4.5 mg (part 3) was administrated after the baseline EGG. Atropine doses of 1.5 and 3.0 mg revealed a similar pattern in the EGG power course. After an initial increase (at the first 15-min interval), the areas of amplitudes decreased back to values comparable with basal levels and subsequently increased significantly again to the maximum at 105 min. The EGG power was quite different after the administration of 4.5 mg of atropine. Areas of amplitudes decreased gradually to the minimum values at 105 min after atropine administration. In conclusion, different dose-dependent changes in the EGG pattern were found after moderate to high doses of atropine.
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