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Is copper imbalance an environmental factor influencing keratoconus development
L. Dudakova, P. Liskova, K. Jirsova,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- biologické modely * MeSH
- enzymy metabolismus MeSH
- keratokonus etiologie MeSH
- lidé MeSH
- měď nedostatek metabolismus MeSH
- rizikové faktory MeSH
- rohovka enzymologie metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Keratoconus is a bilateral disease characterized by progressive corneal thinning leading to irregular astigmatism that results in significant visual impairment. Despite extensive research, the exact etiopathogenesis of keratoconus remains unknown. Many copper-dependent enzymes such as superoxide dismutases, cytochrome c oxidase and lysyl oxidase have been shown to be altered in keratoconic corneas, and a decrease of copper levels in the diseased tissue has been reported as well. We propose a hypothesis linking all the putative pathways of keratoconus development and suggest that copper imbalance in corneal tissue may be an independent risk factor for the disease. The assessment of copper levels and its distribution in keratoconic corneas warrants further investigation.
Citace poskytuje Crossref.org
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- $a Keratoconus is a bilateral disease characterized by progressive corneal thinning leading to irregular astigmatism that results in significant visual impairment. Despite extensive research, the exact etiopathogenesis of keratoconus remains unknown. Many copper-dependent enzymes such as superoxide dismutases, cytochrome c oxidase and lysyl oxidase have been shown to be altered in keratoconic corneas, and a decrease of copper levels in the diseased tissue has been reported as well. We propose a hypothesis linking all the putative pathways of keratoconus development and suggest that copper imbalance in corneal tissue may be an independent risk factor for the disease. The assessment of copper levels and its distribution in keratoconic corneas warrants further investigation.
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