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A genome-wide association study of marginal zone lymphoma shows association to the HLA region
J. Vijai, Z. Wang, SI. Berndt, CF. Skibola, SL. Slager, S. de Sanjose, M. Melbye, B. Glimelius, PM. Bracci, L. Conde, BM. Birmann, SS. Wang, AR. Brooks-Wilson, Q. Lan, PI. de Bakker, RC. Vermeulen, C. Portlock, SM. Ansell, BK. Link, J. Riby, KE....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, práce podpořená grantem, Research Support, U.S. Gov't, P.H.S.
Perzistentní odkaz
https://www.medvik.cz/link/bmc16000401
Online
Plný text
NLK
Directory of Open Access Journals
od 2015
Free Medical Journals
od 2010
Nature Open Access
od 2010-12-01
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2010-01-01
Open Access Digital Library
od 2015-01-01
Open Access Digital Library
od 2015-01-01
Medline Complete (EBSCOhost)
od 2012-11-01
Health & Medicine (ProQuest)
od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2010
PubMed
25569183
DOI
10.1038/ncomms6751
Knihovny.cz E-zdroje
- MeSH
- běloši genetika MeSH
- celogenomová asociační studie MeSH
- genotyp MeSH
- hlavní histokompatibilní komplex genetika MeSH
- jednonukleotidový polymorfismus genetika MeSH
- lidé MeSH
- lymfom z B-buněk marginální zóny genetika MeSH
- membránové glykoproteiny genetika MeSH
- výpočetní biologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, N.I.H., Intramural MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
] Unit of Infections and Cancer Barcelona 8036 Spain
Center For Chronic Immunodeficiency University Medical Center Freiburg Freiburg 79108 Germany
Department of Biomedical Science University of Cagliari Monserrato Cagliari 09042 Italy
Department of Biostatistics Yale School of Public Health New Haven Connecticut 06520 USA
Department of Cancer Etiology City of Hope Beckman Research Institute Duarte California 91030 USA
Department of Epidemiology Harvard School of Public Health Boston Massachusetts 02115 USA
Department of Epidemiology M D Anderson Cancer Center Houston Texas 77030 USA
Department of Health Sciences Research Mayo Clinic Rochester Minnesota 55905 USA
Department of Health Sciences University of York York YO10 5DD UK
Department of Health Studies University of Chicago Chicago Illinois 60637 USA
Department of Medicine Mayo Clinic Rochester Minnesota 55905 USA
Department of Medicine Memorial Sloan Kettering Cancer Center New York New York 10065 USA
Department of Medicine Solna Karolinska Institutet Stockholm 17176 Sweden
Department of Pathological Anatomy University of Bari Bari 70124 Italy
Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda Maryland 20892 USA
Division of Cancer Epidemiology German Cancer Research Center Heidelberg 69120 Germany
Division of Endocrinology Diabetes and Metabolism The Ohio State University Columbus Ohio 43210 USA
Epidemiology Research Program American Cancer Society Atlanta Georgia 30303 USA
Health Studies Sector Westat Rockville Maryland 20850 USA
Interdisciplinary Department of Medicine University of Bari Bari 70124 Italy
Prince of Wales Clinical School University of New South Wales Sydney New South Wales 2052 Australia
School of Nursing and Human Sciences Dublin City University Dublin 9 Ireland
Sydney School of Public Health The University of Sydney Sydney New South Wales 2006 Australia
The Tisch Cancer Institute Icahn School of Medicine at Mount Sinai New York New York 10029 USA
Citace poskytuje Crossref.org
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