• Something wrong with this record ?

Macrophage polarization and activation in response to implant debris: influence by "particle disease" and "ion disease"

YT. Konttinen, J. Pajarinen, Y. Takakubo, J. Gallo, C. Nich, M. Takagi, SB. Goodman,

. 2014 ; 24 (4) : 267-81.

Language English Country United States

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc16000803

Macrophages derive from human embryonic and fetal stem cells and from human bone marrow-derived blood monocytes. They play a major homeostatic role in tissue remodeling and maintenance facilitated by apoptotic "eat me" opsonins like CRP, serum amyloid P, C1q, C3b, IgM, ficolin, and surfactant proteins. Three subsets of monocytes, classic, intermediate, and nonclassic, are mobilized and transmigrate to tissues. Implant-derived wear particles opsonized by danger signals regulate macrophage priming, polarization (M1, M2, M17, and Mreg), and activation. CD14(+) monocytes in healthy controls and CD16(+) monocytes in inflammation differentiate/polarize to foreign body giant cells/osteoclasts or inflammatory dendritic cells (infDC). These danger signal opsonins can be pathogen- or microbe-associated molecular patterns (PAMPs/MAMPs), but in aseptic loosening, usually are damage-associated molecular patterns (DAMPs). Danger signal-opsonized particles elicit "particle disease" and aseptic loosening. They provide soluble and cell membrane-bound co-stimulatory signals that can lead to cell-mediated immune reactions to metal ions. Metal-on-metal implant failure has disclosed that quite like Ni(2+), its neighbor in the periodic table Co(2+) can directly activate toll-like receptor 4 (TLR4) as a lipopolysaccharide-mimic. "Ion disease" concept needs to be incorporated into the "particle disease" concept, due to the toxic, immune, and inflammatory potential of metal ions.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16000803
003      
CZ-PrNML
005      
20160520111611.0
007      
ta
008      
160108s2014 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1615/jlongtermeffmedimplants.2014011355 $2 doi
035    __
$a (PubMed)25747030
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Konttinen, Yrjo T $u Department of Clinical Medicine, University of Helsinki and ORTON Orthopaedic Hospital of the Invalid Foundation, Helsinki, Finland.
245    10
$a Macrophage polarization and activation in response to implant debris: influence by "particle disease" and "ion disease" / $c YT. Konttinen, J. Pajarinen, Y. Takakubo, J. Gallo, C. Nich, M. Takagi, SB. Goodman,
520    9_
$a Macrophages derive from human embryonic and fetal stem cells and from human bone marrow-derived blood monocytes. They play a major homeostatic role in tissue remodeling and maintenance facilitated by apoptotic "eat me" opsonins like CRP, serum amyloid P, C1q, C3b, IgM, ficolin, and surfactant proteins. Three subsets of monocytes, classic, intermediate, and nonclassic, are mobilized and transmigrate to tissues. Implant-derived wear particles opsonized by danger signals regulate macrophage priming, polarization (M1, M2, M17, and Mreg), and activation. CD14(+) monocytes in healthy controls and CD16(+) monocytes in inflammation differentiate/polarize to foreign body giant cells/osteoclasts or inflammatory dendritic cells (infDC). These danger signal opsonins can be pathogen- or microbe-associated molecular patterns (PAMPs/MAMPs), but in aseptic loosening, usually are damage-associated molecular patterns (DAMPs). Danger signal-opsonized particles elicit "particle disease" and aseptic loosening. They provide soluble and cell membrane-bound co-stimulatory signals that can lead to cell-mediated immune reactions to metal ions. Metal-on-metal implant failure has disclosed that quite like Ni(2+), its neighbor in the periodic table Co(2+) can directly activate toll-like receptor 4 (TLR4) as a lipopolysaccharide-mimic. "Ion disease" concept needs to be incorporated into the "particle disease" concept, due to the toxic, immune, and inflammatory potential of metal ions.
650    _2
$a artroplastiky kloubů $7 D019643
650    _2
$a buněčná diferenciace $7 D002454
650    _2
$a polarita buněk $7 D016764
650    _2
$a lidé $7 D006801
650    _2
$a protézy kloubů $x škodlivé účinky $7 D007595
650    _2
$a aktivace makrofágů $7 D008262
650    _2
$a makrofágy $x imunologie $x metabolismus $7 D008264
650    12
$a selhání protézy $7 D011475
655    _2
$a časopisecké články $7 D016428
700    1_
$a Pajarinen, Jukka $u Department of Medicine, Institute of Clinical Medicine, Helsinki University Central Hospital, 00029 HUS, Finland; Department of Orthopaedic Surgery, Stanford Medical Center, Stanford CA 94305-5341 , USA.
700    1_
$a Takakubo, Yuya $u Department of Orthopaedic Surgery, Yamagata University Faculty of Medicine, Yamagata, Japan.
700    1_
$a Gallo, Jiri $u Department of Orthopedics, University Hospital and Faculty of Medicine and Dentistry, Palacky University, Olomouc 775 20, Czech Republic.
700    1_
$a Nich, Christophe $u Laboratoire de Biomecanique et Biomateriaux Osteo-Articulaires - UMR CNRS 7052, Faculte de Medecine - Universite Paris 7, Paris, France; Department of Orthopaedic Surgery, European Teaching Hospital, Assistance Publique - Hopitaux de Paris.
700    1_
$a Takagi, Michiaki $u Department of Orthopaedic Surgery Yamagata University School of Medicine Yamagata, Japan.
700    1_
$a Goodman, Stuart B $u Department of Orthopaedic Surgery Stanford University Medical Center Redwood City, CA.
773    0_
$w MED00188774 $t Journal of long-term effects of medical implants $x 1940-4379 $g Roč. 24, č. 4 (2014), s. 267-81
856    41
$u https://pubmed.ncbi.nlm.nih.gov/25747030 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20160108 $b ABA008
991    __
$a 20160520111723 $b ABA008
999    __
$a ok $b bmc $g 1103084 $s 925009
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 24 $c 4 $d 267-81 $i 1940-4379 $m Journal of long-term effects of medical implants $n J Long Term Eff Med Implants $x MED00188774
LZP    __
$a Pubmed-20160108

Find record

Citation metrics

Archiving options