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Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death
AD. Garg, L. Galluzzi, L. Apetoh, T. Baert, RB. Birge, JM. Bravo-San Pedro, K. Breckpot, D. Brough, R. Chaurio, M. Cirone, A. Coosemans, PG. Coulie, D. De Ruysscher, L. Dini, P. de Witte, AM. Dudek-Peric, A. Faggioni, J. Fucikova, US. Gaipl, J....
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2010
Free Medical Journals
od 2010
PubMed Central
od 2010
Europe PubMed Central
od 2010
Open Access Digital Library
od 2010-01-01
Open Access Digital Library
od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2010
PubMed
26635802
DOI
10.3389/fimmu.2015.00588
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall immunobiology of neoplastic cells. It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called "damage-associated molecular patterns" (DAMPs). The emission of DAMPs and other immunostimulatory factors by cells succumbing to immunogenic cell death (ICD) favors the establishment of a productive interface with the immune system. This results in the elicitation of tumor-targeting immune responses associated with the elimination of residual, treatment-resistant cancer cells, as well as with the establishment of immunological memory. Although ICD has been characterized with increased precision since its discovery, several questions remain to be addressed. Here, we summarize and tabulate the main molecular, immunological, preclinical, and clinical aspects of ICD, in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation.
Biotherapy and Vaccine Unit Institut Pasteur Paris France
Center of Clinical Investigations in Biotherapies of Cancer 507 Villejuif France
Centre Georges François Leclerc Dijon France
Department of Biomedical Molecular Biology Ghent University Ghent Belgium
Department of Ecological and Biological Sciences Tuscia University Viterbo Italy
Department of Experimental Medicine Sapienza University of Rome Rome Italy
Department of Gynaecology and Obstetrics UZ Leuven Leuven Belgium
Department of Immunology Medical University of Warsaw Warsaw Poland
Department of Medical Oncology University Hospital Bern Switzerland
Department of Oncology University of Turin Turin Italy
Department of Radiation Oncology Universitätsklinikum Erlangen Erlangen Germany
Department of Women's and Children's Health Karolinska University Hospital Stockholm Sweden
e Duve Institute Université Catholique de Louvain Brussels Belgium
Equipe 11 Labellisée Ligue Contre le Cancer Centre de Recherche des Cordeliers Paris France
Faculté de Médecine Université de Bourgogne Dijon France
Faculty of Life Sciences University of Manchester Manchester UK
Gustave Roussy Comprehensive Cancer Institute Villejuif France
Helsinki University Hospital Comprehensive Cancer Center Helsinki Finland
Institute of Molecular Biosciences NAWI Graz University of Graz Graz Austria
IRRCS Istituto Scientifico San Raffaele Università Vita Salute San Raffaele Milan Italy
Laboratory of Molecular and Cellular Therapy Vrije Universiteit Brussel Jette Belgium
Molecular Signaling and Cell Death Unit Inflammation Research Center VIB Ghent Belgium
Pôle de Biologie Hôpital Européen Georges Pompidou AP HP Paris France
Sapienza University of Rome Rome Italy
School of Medicine University of Queensland Herston QLD Australia
TILT Biotherapeutics Ltd Helsinki Finland
Université Paris Descartes Sorbonne Paris Cité Paris France
Université Pierre et Marie Curie Paris France
University of Paris Sud Le Kremlin Bicêtre France
Wellman Center for Photomedicine Massachusetts General Hospital Boston MA USA
Citace poskytuje Crossref.org
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