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G-kvadruplexy v oblasti lidských telomer a jejich terapeutický potenciál
[G-quadruplexes in humat telomeric region and their therapeutic potential]

P. Hubálková

. 2015 ; 109 (12) : 918-922.

Jazyk čeština Země Česko

Perzistentní odkaz   https://www.medvik.cz/link/bmc16008258

G-quadruplexes are types of secondary structures of nucleic acids, which are formed in guanine-rich regions. Their existence in vivo was confirmed in promoter regions of some genes and at the end of chromosomes in the telomeric regions. The specific structure of G-quadruplexes is a promising target in cancer treatment. There is a search for small ligands, which could stabilize a specific type of G-quadruplexes. Cancer cells are markedly different from normal cells in the telomeric region: the regions are profoundly shorter. Telomeric regions in cancer cells are prolonged by an enzyme telomerase, while this enzyme is inactive in almost all somatic cells. Stabilization of telomeric G-quadruplex by a specific small ligand induces disruption of a normal protective function of telomers leading to cell damage and its death. This approach could be successful in cancer treatment.

G-quadruplexes in humat telomeric region and their therapeutic potential

Bibliografie atd.

Literatura

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