Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Anthocyanin-rich diet in chemically induced colitis in mice

K. Janšáková, J. Bábíčková, B. Filová, E. Lengyelová, M. Havrlentová, J. Kraic, P. Celec, Ľ. Tóthová

. 2015 ; 61 (3) : 104-109.

Language English Country Czech Republic

Document type Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc16013746

The aetiology of inflammatory bowel diseases is unclear, but oxidative stress plays a key role in the pathogenesis. Anthocyanins--plant polyphenols--were shown to have antioxidant and anti-inflammatory properties. The aim of this study was to investigate the potential protective effects of anthocyanins on the oxidative status in mice with chemically induced colitis. Adult male mice were randomly divided into a control group drinking tap water and a colitis group drinking 1% dextran sulphate sodium solution. Animals had ad libitum access to a control wheat-based diet or food based on wheat producing anthocyanins. Bodyweight and stool consistency were monitored daily for 14 days. At the end of the experiment, colon length was measured and tissue samples were collected for the assessment of histology and oxidative status. Mice with colitis had lower body weight, higher stool score and shorter colon than control mice. Anthocyanins had neither an effect on stool consistency, nor on bodyweight loss and colon length. In the colon, liver and plasma, analysis of oxidative stress markers and antioxidant status revealed no significant differences between the groups. Food made from wheat producing anthocyanins did not protect mice from the consequences of chemically induced colitis. The measured biomarkers do not confirm the role of oxidative stress in this model of colitis. Further optimization of the anthocyanin-rich food might be needed before further experiments are conducted.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16013746
003      
CZ-PrNML
005      
20160531133840.0
007      
ta
008      
160506s2015 xr d f 000 0|eng||
009      
AR
024    __
$a 10.14712/fb2015061030104 $2 doi
035    __
$a (PubMed)26213856
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Janšáková, Katarína $u Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia $7 xx0232724
245    10
$a Anthocyanin-rich diet in chemically induced colitis in mice / $c K. Janšáková, J. Bábíčková, B. Filová, E. Lengyelová, M. Havrlentová, J. Kraic, P. Celec, Ľ. Tóthová
520    9_
$a The aetiology of inflammatory bowel diseases is unclear, but oxidative stress plays a key role in the pathogenesis. Anthocyanins--plant polyphenols--were shown to have antioxidant and anti-inflammatory properties. The aim of this study was to investigate the potential protective effects of anthocyanins on the oxidative status in mice with chemically induced colitis. Adult male mice were randomly divided into a control group drinking tap water and a colitis group drinking 1% dextran sulphate sodium solution. Animals had ad libitum access to a control wheat-based diet or food based on wheat producing anthocyanins. Bodyweight and stool consistency were monitored daily for 14 days. At the end of the experiment, colon length was measured and tissue samples were collected for the assessment of histology and oxidative status. Mice with colitis had lower body weight, higher stool score and shorter colon than control mice. Anthocyanins had neither an effect on stool consistency, nor on bodyweight loss and colon length. In the colon, liver and plasma, analysis of oxidative stress markers and antioxidant status revealed no significant differences between the groups. Food made from wheat producing anthocyanins did not protect mice from the consequences of chemically induced colitis. The measured biomarkers do not confirm the role of oxidative stress in this model of colitis. Further optimization of the anthocyanin-rich food might be needed before further experiments are conducted.
650    _2
$a zvířata $7 D000818
650    _2
$a anthokyaniny $x farmakologie $x terapeutické užití $7 D000872
650    _2
$a antioxidancia $x farmakologie $x terapeutické užití $7 D000975
650    _2
$a biologické markery $x metabolismus $7 D015415
650    _2
$a kolitida $x chemicky indukované $x dietoterapie $x patologie $x patofyziologie $7 D003092
650    _2
$a kolon $x účinky léků $x patologie $7 D003106
650    12
$a fortifikované potraviny $7 D005527
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a myši $7 D051379
650    _2
$a oxidační stres $x účinky léků $7 D018384
650    _2
$a náhodné rozdělení $7 D011897
650    _2
$a výsledek terapie $7 D016896
650    _2
$a pšenice $7 D014908
650    _2
$a hmotnostní úbytek $x účinky léků $7 D015431
655    _2
$a hodnotící studie $7 D023362
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Bábíčková, Janka. $u Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia; Center for Molecular Medicine, Slovak Academy of Sciences, Bratislava, Slovakia $7 xx0229065
700    1_
$a Filová, B. $u Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia $7 _AN083026
700    1_
$a Lengyelová, Eva. $u Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia $7 xx0243696
700    1_
$a Havrlentová, Michaela $u National Agricultural and Food Centre – Research Institute of Plant Production, Piešťany, Slovakia; Department of Biotechnologies, Faculty of Natural Sciences, University of SS. Cyril and Methodius, Trnava, Slovakia $7 xx0267047
700    1_
$a Kraic, Ján $u National Agricultural and Food Centre – Research Institute of Plant Production, Piešťany, Slovakia; Department of Biotechnologies, Faculty of Natural Sciences, University of SS. Cyril and Methodius, Trnava, Slovakia $7 _BN001371
700    1_
$a Celec, Peter $u Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia; Center for Molecular Medicine, Slovak Academy of Sciences, Bratislava, Slovakia; Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia; Department of Molecular Biology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia $7 xx0073731
700    1_
$a Tóthová, Ľubomíra. $u Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia; Center for Molecular Medicine, Slovak Academy of Sciences, Bratislava, Slovakia $7 xx0229262
773    0_
$w MED00011004 $t Folia biologica $x 0015-5500 $g Roč. 61, č. 3 (2015), s. 104-109
856    41
$u https://fb.cuni.cz/file/5779/fb2015a0014.pdf $y plný text volně přístupný
910    __
$a ABA008 $b A 970 $c 89 $y 4 $z 0
990    __
$a 20160506 $b ABA008
991    __
$a 20160531134001 $b ABA008
999    __
$a ok $b bmc $g 1126042 $s 938158
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2015 $b 61 $c 3 $d 104-109 $i 0015-5500 $m Folia biologica (Praha) $n Folia biol. (Praha) $x MED00011004
LZP    __
$b NLK118 $a Pubmed-20160506

Find record

Citation metrics

Archiving options