• Je něco špatně v tomto záznamu ?

HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy

L. Janeckova, M. Kolar, J. Svec, L. Lanikova, V. Pospichalova, N. Baloghova, M. Vojtechova, E. Sloncova, H. Strnad, V. Korinek,

. 2016 ; 9 (2) : 99-107. [pub] 20160304

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc16019956

Neoplastic growth is frequently associated with genomic DNA methylation that causes transcriptional silencing of tumor suppressor genes. We used a collection of colorectal polyps and carcinomas in combination with bioinformatics analysis of large datasets to study the expression and methylation of Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene inactivated in many neoplasms. In premalignant stages, HIC1 expression was decreased, and the decrease was linked to methylation of a specific region in the HIC1 locus. However, in carcinomas, the HIC1 expression was variable and, in some specimens, comparable to healthy tissue. Importantly, high HIC1 production distinguished a specific type of chemotherapy-responsive tumors.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16019956
003      
CZ-PrNML
005      
20160728122327.0
007      
ta
008      
160722s2016 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.tranon.2016.01.005 $2 doi
024    7_
$a 10.1016/j.tranon.2016.01.005 $2 doi
035    __
$a (PubMed)27084425
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Janeckova, Lucie $u Department of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic.
245    10
$a HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy / $c L. Janeckova, M. Kolar, J. Svec, L. Lanikova, V. Pospichalova, N. Baloghova, M. Vojtechova, E. Sloncova, H. Strnad, V. Korinek,
520    9_
$a Neoplastic growth is frequently associated with genomic DNA methylation that causes transcriptional silencing of tumor suppressor genes. We used a collection of colorectal polyps and carcinomas in combination with bioinformatics analysis of large datasets to study the expression and methylation of Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene inactivated in many neoplasms. In premalignant stages, HIC1 expression was decreased, and the decrease was linked to methylation of a specific region in the HIC1 locus. However, in carcinomas, the HIC1 expression was variable and, in some specimens, comparable to healthy tissue. Importantly, high HIC1 production distinguished a specific type of chemotherapy-responsive tumors.
655    _2
$a časopisecké články $7 D016428
700    1_
$a Kolar, Michal $u Department of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic.
700    1_
$a Svec, Jiri $u Department of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic; Department of Radiotherapy and Oncology, Third Faculty of Medicine, Charles University, Prague, Srobarova 50, 100 34 Prague 4, Czech Republic.
700    1_
$a Lanikova, Lucie $u Department of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic.
700    1_
$a Pospichalova, Vendula $u Department of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic.
700    1_
$a Baloghova, Nikol $u Department of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic.
700    1_
$a Vojtechova, Martina $u Department of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic.
700    1_
$a Sloncova, Eva $u Department of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic.
700    1_
$a Strnad, Hynek $u Department of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic.
700    1_
$a Korinek, Vladimir $u Department of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic; Division BIOCEV, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic. Electronic address: korinek@img.cas.cz.
773    0_
$w MED00177205 $t Translational oncology $x 1936-5233 $g Roč. 9, č. 2 (2016), s. 99-107
856    41
$u https://pubmed.ncbi.nlm.nih.gov/27084425 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20160722 $b ABA008
991    __
$a 20160728122549 $b ABA008
999    __
$a ind $b bmc $g 1154626 $s 944484
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 9 $c 2 $d 99-107 $e 20160304 $i 1936-5233 $m Translational oncology $n Transl Oncol $x MED00177205
LZP    __
$a Pubmed-20160722

Najít záznam

Citační ukazatele

Možnosti archivace