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The primary motor cortex is involved in the control of a non-motor cognitive action

M. Kukleta, A. Damborská, R. Roman, I. Rektor, M. Brázdil,

. 2016 ; 127 (2) : 1547-50. [pub] 20151211

Language English Country Netherlands

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc16020065

OBJECTIVE: Adaptive interactions with the outer world necessitate effective connections between cognitive and executive functions. The primary motor cortex (M1) with its control of the spinal cord motor apparatus and its involvement in the processing of cognitive information related to motor functions is one of the best suited structures of this cognition-action connection. The question arose whether M1 might be involved also in situations where no overt or covered motor action is present. METHODS: The EEG data analyzed were recorded during an oddball task in one epileptic patient (19 years) with depth multilead electrodes implanted for diagnostic reasons into the M1 and several prefrontal areas. RESULTS: The main result was the finding of an evoked response to non-target stimuli with a pronounced late component in all frontal areas explored, including three loci of the M1. The late component was implicated in the evaluation of predicted and actual action and was synchronized in all three precentral loci and in the majority of prefrontal loci. CONCLUSION: The finding is considered as direct evidence of functional involvement of the M1 in cognitive activity not related to motor function. SIGNIFICANCE: Our results contribute to better understanding of neural mechanisms underlying cognition.

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$a OBJECTIVE: Adaptive interactions with the outer world necessitate effective connections between cognitive and executive functions. The primary motor cortex (M1) with its control of the spinal cord motor apparatus and its involvement in the processing of cognitive information related to motor functions is one of the best suited structures of this cognition-action connection. The question arose whether M1 might be involved also in situations where no overt or covered motor action is present. METHODS: The EEG data analyzed were recorded during an oddball task in one epileptic patient (19 years) with depth multilead electrodes implanted for diagnostic reasons into the M1 and several prefrontal areas. RESULTS: The main result was the finding of an evoked response to non-target stimuli with a pronounced late component in all frontal areas explored, including three loci of the M1. The late component was implicated in the evaluation of predicted and actual action and was synchronized in all three precentral loci and in the majority of prefrontal loci. CONCLUSION: The finding is considered as direct evidence of functional involvement of the M1 in cognitive activity not related to motor function. SIGNIFICANCE: Our results contribute to better understanding of neural mechanisms underlying cognition.
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$a Damborská, Alena $u CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic; Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. Electronic address: adambor@med.muni.cz.
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$a Roman, Robert $u CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic; Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
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$a Rektor, Ivan $u CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic; 1st Department of Neurology, St. Anne's Faculty Hospital, Masaryk University, Brno, Czech Republic.
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$a Brázdil, Milan $u CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic; 1st Department of Neurology, St. Anne's Faculty Hospital, Masaryk University, Brno, Czech Republic.
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