Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites

YH. Woo, H. Ansari, TD. Otto, CM. Klinger, M. Kolisko, J. Michálek, A. Saxena, D. Shanmugam, A. Tayyrov, A. Veluchamy, S. Ali, A. Bernal, J. del Campo, J. Cihlář, P. Flegontov, SG. Gornik, E. Hajdušková, A. Horák, J. Janouškovec, NJ. Katris, FD....

. 2015 ; 4 (-) : e06974. [pub] 20150715

Language English Country England, Great Britain

Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc16020540

The eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular parasites of humans and animals with immense socio-economic and health impacts. We sequenced nuclear genomes of Chromera velia and Vitrella brassicaformis, free-living non-parasitic photosynthetic algae closely related to apicomplexans. Proteins from key metabolic pathways and from the endomembrane trafficking systems associated with a free-living lifestyle have been progressively and non-randomly lost during adaptation to parasitism. The free-living ancestor contained a broad repertoire of genes many of which were repurposed for parasitic processes, such as extracellular proteins, components of a motility apparatus, and DNA- and RNA-binding protein families. Based on transcriptome analyses across 36 environmental conditions, Chromera orthologs of apicomplexan invasion-related motility genes were co-regulated with genes encoding the flagellar apparatus, supporting the functional contribution of flagella to the evolution of invasion machinery. This study provides insights into how obligate parasites with diverse life strategies arose from a once free-living phototrophic marine alga.

Biochemical Sciences Division CSIR National Chemical Laboratory Pune India

Bioscience Core Laboratory King Abdullah University of Science and Technology Thuwal Saudi Arabia

Broad Genome Sequencing and Analysis Program Broad Institute of MIT and Harvard Cambridge United States

Canadian Institute for Advanced Research Department of Botany University of British Columbia Vancouver Canada

Centre for GeoGenetics Natural History Museum of Denmark University of Copenhagen Copenhagen Denmark

Centro de Biología Molecular Severo Ochoa CSIC Universidad Autónoma de Madrid Madrid Spain

Department of Biology University of Pennsylvania Philadelphia United States

Department of Cell Biology University of Alberta Edmonton Canada

Department of Microbiology and Immunology Weill Cornell Medical College New York United States

Department of Microbiology Monash University Clayton Australia

Ecology and Evolutionary Biology Section Institut de Biologie de l'Ecole Normale Supérieure CNRS UMR8197 INSERM U1024 Paris France

European Bioinformatics Institute Wellcome Genome Campus Hinxton Cambridge United Kingdom

Institute of Parasitology Biology Centre Czech Academy of Sciences České Budějovice Czech Republic

Parasite Genomics Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Cambridge United Kingdom

Pathogen Genomics Laboratory Biological and Environmental Sciences and Engineering Division King Abdullah University of Science and Technology Thuwal Saudi Arabia

School of Botany University of Melbourne Parkville Australia

Seattle Biomedical Research Institute Seattle United States

Wellcome Trust Centre For Molecular Parasitology Institute of Infection Immunity and Inflammation College of Medical Veterinary and Life Sciences University of Glasgow Glasgow United Kingdom

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16020540
003      
CZ-PrNML
005      
20180102092300.0
007      
ta
008      
160722s2015 enk f 000 0|eng||
009      
AR
024    7_
$a 10.7554/eLife.06974 $2 doi
024    7_
$a 10.7554/eLife.06974 $2 doi
035    __
$a (PubMed)26175406
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Woo, Yong H $u Pathogen Genomics Laboratory, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
245    10
$a Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites / $c YH. Woo, H. Ansari, TD. Otto, CM. Klinger, M. Kolisko, J. Michálek, A. Saxena, D. Shanmugam, A. Tayyrov, A. Veluchamy, S. Ali, A. Bernal, J. del Campo, J. Cihlář, P. Flegontov, SG. Gornik, E. Hajdušková, A. Horák, J. Janouškovec, NJ. Katris, FD. Mast, D. Miranda-Saavedra, T. Mourier, R. Naeem, M. Nair, AK. Panigrahi, ND. Rawlings, E. Padron-Regalado, A. Ramaprasad, N. Samad, A. Tomčala, J. Wilkes, DE. Neafsey, C. Doerig, C. Bowler, PJ. Keeling, DS. Roos, JB. Dacks, TJ. Templeton, RF. Waller, J. Lukeš, M. Oborník, A. Pain,
520    9_
$a The eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular parasites of humans and animals with immense socio-economic and health impacts. We sequenced nuclear genomes of Chromera velia and Vitrella brassicaformis, free-living non-parasitic photosynthetic algae closely related to apicomplexans. Proteins from key metabolic pathways and from the endomembrane trafficking systems associated with a free-living lifestyle have been progressively and non-randomly lost during adaptation to parasitism. The free-living ancestor contained a broad repertoire of genes many of which were repurposed for parasitic processes, such as extracellular proteins, components of a motility apparatus, and DNA- and RNA-binding protein families. Based on transcriptome analyses across 36 environmental conditions, Chromera orthologs of apicomplexan invasion-related motility genes were co-regulated with genes encoding the flagellar apparatus, supporting the functional contribution of flagella to the evolution of invasion machinery. This study provides insights into how obligate parasites with diverse life strategies arose from a once free-living phototrophic marine alga.
650    _2
$a Alveolata $x genetika $7 D056893
650    _2
$a DNA řas $x chemie $x genetika $7 D048028
650    12
$a molekulární evoluce $7 D019143
650    _2
$a stanovení celkové genové exprese $7 D020869
650    _2
$a molekulární sekvence - údaje $7 D008969
650    12
$a sekvenční analýza DNA $7 D017422
655    _2
$a časopisecké články $7 D016428
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Ansari, Hifzur $u Pathogen Genomics Laboratory, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia. $7 gn_A_00007187
700    1_
$a Otto, Thomas D $u Parasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom.
700    1_
$a Klinger, Christen M $u Department of Cell Biology, University of Alberta, Edmonton, Canada.
700    1_
$a Kolisko, Martin $u Canadian Institute for Advanced Research, Department of Botany, University of British Columbia, Vancouver, Canada.
700    1_
$a Michálek, Jan $u Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.
700    1_
$a Saxena, Alka $u Pathogen Genomics Laboratory, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
700    1_
$a Shanmugam, Dhanasekaran $u Biochemical Sciences Division, CSIR National Chemical Laboratory, Pune, India.
700    1_
$a Tayyrov, Annageldi $u Pathogen Genomics Laboratory, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
700    1_
$a Veluchamy, Alaguraj $u Ecology and Evolutionary Biology Section, Institut de Biologie de l'Ecole Normale Supérieure, CNRS UMR8197 INSERM U1024, Paris, France.
700    1_
$a Ali, Shahjahan $u Bioscience Core Laboratory, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia. $7 gn_A_00004191
700    1_
$a Bernal, Axel $u Department of Biology, University of Pennsylvania, Philadelphia, United States.
700    1_
$a del Campo, Javier $u Canadian Institute for Advanced Research, Department of Botany, University of British Columbia, Vancouver, Canada.
700    1_
$a Cihlář, Jaromír $u Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.
700    1_
$a Flegontov, Pavel $u Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.
700    1_
$a Gornik, Sebastian G $u School of Botany, University of Melbourne, Parkville, Australia.
700    1_
$a Hajdušková, Eva $u Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.
700    1_
$a Horák, Aleš $u Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.
700    1_
$a Janouškovec, Jan $u Canadian Institute for Advanced Research, Department of Botany, University of British Columbia, Vancouver, Canada.
700    1_
$a Katris, Nicholas J $u School of Botany, University of Melbourne, Parkville, Australia.
700    1_
$a Mast, Fred D $u Seattle Biomedical Research Institute, Seattle, United States.
700    1_
$a Miranda-Saavedra, Diego $u Centro de Biología Molecular Severo Ochoa, CSIC/Universidad Autónoma de Madrid, Madrid, Spain.
700    1_
$a Mourier, Tobias $u Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.
700    1_
$a Naeem, Raeece $u Pathogen Genomics Laboratory, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
700    1_
$a Nair, Mridul $u Pathogen Genomics Laboratory, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
700    1_
$a Panigrahi, Aswini K $u Bioscience Core Laboratory, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
700    1_
$a Rawlings, Neil D. $7 xx0046074 $u European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.
700    1_
$a Padron-Regalado, Eriko $u Pathogen Genomics Laboratory, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
700    1_
$a Ramaprasad, Abhinay $u Pathogen Genomics Laboratory, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
700    1_
$a Samad, Nadira $u School of Botany, University of Melbourne, Parkville, Australia.
700    1_
$a Tomčala, Aleš $u Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.
700    1_
$a Wilkes, Jon $u Wellcome Trust Centre For Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
700    1_
$a Neafsey, Daniel E $u Broad Genome Sequencing and Analysis Program, Broad Institute of MIT and Harvard, Cambridge, United States.
700    1_
$a Doerig, Christian $u Department of Microbiology, Monash University, Clayton, Australia.
700    1_
$a Bowler, Chris $u Ecology and Evolutionary Biology Section, Institut de Biologie de l'Ecole Normale Supérieure, CNRS UMR8197 INSERM U1024, Paris, France.
700    1_
$a Keeling, Patrick J $u Canadian Institute for Advanced Research, Department of Botany, University of British Columbia, Vancouver, Canada.
700    1_
$a Roos, David S $u Department of Biology, University of Pennsylvania, Philadelphia, United States.
700    1_
$a Dacks, Joel B $u Department of Cell Biology, University of Alberta, Edmonton, Canada.
700    1_
$a Templeton, Thomas J $u Department of Microbiology and Immunology, Weill Cornell Medical College, New York, United States.
700    1_
$a Waller, Ross F $u School of Botany, University of Melbourne, Parkville, Australia.
700    1_
$a Lukeš, Julius $u Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.
700    1_
$a Oborník, Miroslav $u Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.
700    1_
$a Pain, Arnab $u Pathogen Genomics Laboratory, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
773    0_
$w MED00188753 $t eLife $x 2050-084X $g Roč. 4, č. - (2015), s. e06974
856    41
$u https://pubmed.ncbi.nlm.nih.gov/26175406 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20160722 $b ABA008
991    __
$a 20180102092515 $b ABA008
999    __
$a ok $b bmc $g 1155210 $s 945068
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2015 $b 4 $c - $d e06974 $e 20150715 $i 2050-084X $m eLife $n eLife $x MED00188753
LZP    __
$a Pubmed-20160722

Find record

Citation metrics

Archiving options