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Intracellular microRNA profiles form in the Xenopus laevis oocyte that may contribute to asymmetric cell division
M. Sidova, R. Sindelka, M. Castoldi, V. Benes, M. Kubista,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
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PubMed
26059897
DOI
10.1038/srep11157
Knihovny.cz E-resources
- MeSH
- Cell Division genetics MeSH
- MicroRNAs genetics MeSH
- Oocytes metabolism MeSH
- Xenopus laevis MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Asymmetric distribution of fate determinants within cells is an essential biological strategy to prepare them for asymmetric division. In this work we measure the intracellular distribution of 12 maternal microRNAs (miRNA) along the animal-vegetal axis of the Xenopus laevis oocyte using qPCR tomography. We find the miRNAs have distinct intracellular profiles that resemble two out of the three profiles we previously observed for mRNAs. Our results suggest that miRNAs in addition to proteins and mRNAs may have asymmetric distribution within the oocyte and may contribute to asymmetric cell division as cell fate determinants.
References provided by Crossref.org
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- $a Sidova, Monika $u 1] Laboratory of Gene Expression, Institute of Biotechnology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague, 142 20 Czech Republic [2] Charles University in Prague, Faculty of Science, Department of Cell Biology, Vinicna 7, Prague, 128 43, Czech Republic.
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- $a Asymmetric distribution of fate determinants within cells is an essential biological strategy to prepare them for asymmetric division. In this work we measure the intracellular distribution of 12 maternal microRNAs (miRNA) along the animal-vegetal axis of the Xenopus laevis oocyte using qPCR tomography. We find the miRNAs have distinct intracellular profiles that resemble two out of the three profiles we previously observed for mRNAs. Our results suggest that miRNAs in addition to proteins and mRNAs may have asymmetric distribution within the oocyte and may contribute to asymmetric cell division as cell fate determinants.
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- $a Kubista, Mikael $u 1] Laboratory of Gene Expression, Institute of Biotechnology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague, 142 20 Czech Republic [2] TATAA Biocenter AB, Odinsgatan 28, Göteborg, 411 03 Sweden.
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