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Characterization of a new human plasma cell leukemia cell line UHKT-944

I. Vyhlídalová, L. Uherková, M. Pleschnerová, I. Špička, J. Březinová, K. Michalová, K. Čermáková, V. Polanská, PL. Jedelský, E. Hamšíková, K. Kuželová, P. Stöckbauer,

. 2015 ; 95 (4) : 352-60. [pub] 20150313

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu kazuistiky, časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc16020997

OBJECTIVE: A new interleukin-6 (IL-6)-dependent plasma cell leukemia cell line UHKT-944 was established from bone marrow cells derived from a 55-yr-old man with plasma cell leukemia. RESULTS: The cell line possesses phenotypic characteristics of plasma cells including the production of a monoclonal immunoglobulin IgA1-kappa. VH3-9 region of IgVH genes was rearranged and somatically hypermutated. The UHKT-944 cells were found to be negative for most of tested B-cell, T-cell, and myeloid markers. According to cytogenetic analysis, the cells were classified as near tetraploid with several numerical and structural abnormalities including the t(14;20) involving IgH locus. CONCLUSION: The established permanent plasma cell leukemia cell line is a suitable model for the study of cellular and molecular mechanisms of pathogenesis of this rare malignant disease.

Citace poskytuje Crossref.org

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$a Uherková, Lenka $u Department of Cellular Biochemistry, Institute of Hematology and Blood Transfusion (IHBT), Prague, Czech Republic.
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$a Pleschnerová, Markéta $u Department of Immunology, Faculty of Science, Charles University, Prague, Czech Republic.
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$a Špička, Ivan $u 1st Department of Internal Medicine, Division of Hematology, General Faculty Hospital, Charles University, Prague, Czech Republic.
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$a Březinová, Jana $u Department of Cytogenetics, IHBT, Prague, Czech Republic.
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$a Čermáková, Kamila $u Leukemia PCR Diagnostics Laboratory, IHBT, Prague, Czech Republic.
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$a Jedelský, Petr L $u Faculty of Science, Charles University, Prague, Czech Republic. Faculty of Arts, Charles University, Prague, Czech Republic.
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$a Hamšíková, Eva $u Department of Experimental Virology, IHBT, Prague, Czech Republic.
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$a Kuželová, Kateřina $u Department of Cellular Biochemistry, Institute of Hematology and Blood Transfusion (IHBT), Prague, Czech Republic.
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