• Je něco špatně v tomto záznamu ?

A single reference measurement can predict liver tumor motion during respiration

J. Cvek, L. Knybel, L. Molenda, B. Otahal, T. Jonszta, D. Czerny, D. Feltl,

. 2015 ; 21 (3) : 278-83. [pub] 20151229

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc16027420

AIM: To evaluate liver tumor motion and how well reference measurement predicts motion during treatment. MATERIAL AND METHODS: This retrospective study included 20 patients with colorectal cancer that had metastasized to the liver who were treated with stereotactic ablative radiotherapy. An online respiratory tumor tracking system was used. Tumor motion amplitudes in the superior-inferior (SI), latero-lateral (LL), and anterior-posterior (AP) directions were collected to generate patient-specific margins. Reference margins were generated as the mean motion and 95th percentile of motion from measurements recorded for different lengths of time (1, 3, and 5 min). We analyzed the predictability of tumor motion in each axis, based on the reference measurement and intra-/interfraction motions. RESULTS: About 96,000 amplitudes were analyzed. The mean tumor motions were 9.9 ± 4.2 mm, 2.6 ± 0.8 mm, and 4.5 ± 1.8 mm in the SI, LL, and AP directions, respectively. The intrafraction variations were 3.5 ± 1.8 mm, 0.63 ± 0.35 mm, and 1.4 ± 0.65 mm for the SI, LL, and AP directions, respectively. The interfraction motion variations were 1.32 ± 0.79 mm, 0.31 ± 0.23 mm, and 0.68 ± 0.62 mm for the SI, LL, and AP directions, respectively. The Pearson's correlation coefficients for margins based on the reference measurement (mean motion or 95th percentile) and margins covering 95% of the motion during the whole treatment were 0.8-0.91, 0.57-0.7, and 0.77-0.82 in the SI, LL, and AP directions, respectively. CONCLUSION: Liver tumor motion in the SI direction can be adequately represented by the mean tumor motion amplitude generated from a single 1 min reference measurement. Longer reference measurements did not improve results for patients who were well-educated about the importance of regular breathing. Although the study was based on tumor tracking data, the results are useful for ITV delineation when tumor tracking is not available.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16027420
003      
CZ-PrNML
005      
20161031114500.0
007      
ta
008      
161005s2015 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.rpor.2015.11.003 $2 doi
024    7_
$a 10.1016/j.rpor.2015.11.003 $2 doi
035    __
$a (PubMed)27601962
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Cvek, Jakub $u Dept. of Oncology, University Hospital Ostrava, Ostrava, Czech Republic.
245    12
$a A single reference measurement can predict liver tumor motion during respiration / $c J. Cvek, L. Knybel, L. Molenda, B. Otahal, T. Jonszta, D. Czerny, D. Feltl,
520    9_
$a AIM: To evaluate liver tumor motion and how well reference measurement predicts motion during treatment. MATERIAL AND METHODS: This retrospective study included 20 patients with colorectal cancer that had metastasized to the liver who were treated with stereotactic ablative radiotherapy. An online respiratory tumor tracking system was used. Tumor motion amplitudes in the superior-inferior (SI), latero-lateral (LL), and anterior-posterior (AP) directions were collected to generate patient-specific margins. Reference margins were generated as the mean motion and 95th percentile of motion from measurements recorded for different lengths of time (1, 3, and 5 min). We analyzed the predictability of tumor motion in each axis, based on the reference measurement and intra-/interfraction motions. RESULTS: About 96,000 amplitudes were analyzed. The mean tumor motions were 9.9 ± 4.2 mm, 2.6 ± 0.8 mm, and 4.5 ± 1.8 mm in the SI, LL, and AP directions, respectively. The intrafraction variations were 3.5 ± 1.8 mm, 0.63 ± 0.35 mm, and 1.4 ± 0.65 mm for the SI, LL, and AP directions, respectively. The interfraction motion variations were 1.32 ± 0.79 mm, 0.31 ± 0.23 mm, and 0.68 ± 0.62 mm for the SI, LL, and AP directions, respectively. The Pearson's correlation coefficients for margins based on the reference measurement (mean motion or 95th percentile) and margins covering 95% of the motion during the whole treatment were 0.8-0.91, 0.57-0.7, and 0.77-0.82 in the SI, LL, and AP directions, respectively. CONCLUSION: Liver tumor motion in the SI direction can be adequately represented by the mean tumor motion amplitude generated from a single 1 min reference measurement. Longer reference measurements did not improve results for patients who were well-educated about the importance of regular breathing. Although the study was based on tumor tracking data, the results are useful for ITV delineation when tumor tracking is not available.
655    _2
$a časopisecké články $7 D016428
700    1_
$a Knybel, Lukas $u VŠB-Technical University of Ostrava, Ostrava, Czech Republic.
700    1_
$a Molenda, Lukas $u Dept. of Oncology, University Hospital Ostrava, Ostrava, Czech Republic.
700    1_
$a Otahal, Bretislav $u Dept. of Oncology, University Hospital Ostrava, Ostrava, Czech Republic.
700    1_
$a Jonszta, Tomas $u Dept. of Radiology, University Hospital Ostrava, Ostrava, Czech Republic.
700    1_
$a Czerny, Daniel $u Dept. of Radiology, University Hospital Ostrava, Ostrava, Czech Republic.
700    1_
$a Feltl, David $u Dept. of Oncology, University Hospital Ostrava, Ostrava, Czech Republic.
773    0_
$w MED00154188 $t Reports of practical oncology and radiotherapy journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology $x 1507-1367 $g Roč. 21, č. 3 (2015), s. 278-83
856    41
$u https://pubmed.ncbi.nlm.nih.gov/27601962 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20161005 $b ABA008
991    __
$a 20161031114424 $b ABA008
999    __
$a ind $b bmc $g 1165734 $s 952050
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2015 $b 21 $c 3 $d 278-83 $e 20151229 $i 1507-1367 $m Reports of Practical Oncology and Radiotherapy $n Rep Pract Oncol Radiother $x MED00154188
LZP    __
$a Pubmed-20161005

Najít záznam

Citační ukazatele

    Možnosti archivace