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Highly efficient mesenchymal stem cell proliferation on poly-ε-caprolactone nanofibers with embedded magnetic nanoparticles
J. Daňková, M. Buzgo, J. Vejpravová, S. Kubíčková, V. Sovková, L. Vysloužilová, A. Mantlíková, A. Nečas, E. Amler,
Language English Country New Zealand
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NT12156
MZ0
CEP Register
Digital library NLK
Full text - Article
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PubMed
26677321
DOI
10.2147/ijn.s93670
Knihovny.cz E-resources
- MeSH
- Biocompatible Materials chemistry pharmacology MeSH
- Cell Adhesion drug effects MeSH
- Cell Differentiation drug effects MeSH
- Caproates chemistry pharmacology MeSH
- Lactones chemistry pharmacology MeSH
- Magnetite Nanoparticles chemistry MeSH
- Mesenchymal Stem Cells cytology drug effects MeSH
- Nanofibers chemistry MeSH
- Polyesters pharmacology MeSH
- Swine MeSH
- Cell Proliferation drug effects MeSH
- Tissue Engineering MeSH
- Tissue Scaffolds chemistry MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
In this study, we have developed a combined approach to accelerate the proliferation of mesenchymal stem cells (MSCs) in vitro, using a new nanofibrous scaffold made by needleless electrospinning from a mixture of poly-ε-caprolactone and magnetic particles. The biological characteristics of porcine MSCs were investigated while cultured in vitro on composite scaffold enriched with magnetic nanoparticles. Our data indicate that due to the synergic effect of the poly-ε-caprolactone nanofibers and magnetic particles, cellular adhesion and proliferation of MSCs is enhanced and osteogenic differentiation is supported. The cellular and physical attributes make this new scaffold very promising for the acceleration of efficient MSC proliferation and regeneration of hard tissues.
Faculty of Biomedical Engineering Czech Technical University Prague Kladno Czech Republic
Institute of Biophysics 2nd Faculty of Medicine Charles University Prague Prague Czech Republic
References provided by Crossref.org
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