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Orthostatic hypotension is associated with decreased cerebrospinal fluid levels of chromogranin A in early stage of Parkinson disease

M. Kaiserova, H. Prikrylova Vranova, J. Galuszka, D. Stejskal, K. Mensikova, J. Zapletalova, J. Mares, P. Kanovsky,

. 2015 ; 25 (5) : 339-342. [pub] 20150910

Language English Country Germany

Document type Journal Article, Research Support, Non-U.S. Gov't

Grant support
NT12221 MZ0 CEP Register

Digital library NLK
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NLK ProQuest Central from 2002-02-01 to 2019-01-31
Medline Complete (EBSCOhost) from 2003-02-01 to 1 year ago
Health & Medicine (ProQuest) from 2002-02-01 to 2019-01-31

An association between the CSF chromogranin A (CgA) and orthostatic blood pressure changes was investigated in 20 patients in the early stage of Parkinson disease (PD). There was a positive correlation between the CSF CgA and diastolic blood pressure change, when CSF CgA levels were lower in patients with orthostatic hypotension (OH). Decreased CSF CgA may be useful in predicting OH in the early stage of PD.

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