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The harmful chemistry behind "krokodil": Street-like synthesis and product analysis

EA. Alves, JX. Soares, CM. Afonso, JP. Grund, AS. Agonia, SM. Cravo, AD. Netto, F. Carvalho, RJ. Dinis-Oliveira,

. 2015 ; 257 (-) : 76-82. [pub] 20150803

Jazyk angličtina Země Irsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc16028300
E-zdroje Online Plný text

NLK ProQuest Central od 1997-02-07 do Před 2 měsíci
Nursing & Allied Health Database (ProQuest) od 1997-02-07 do Před 2 měsíci
Health & Medicine (ProQuest) od 1997-02-07 do Před 2 měsíci

Odkazy

PubMed 26282512
DOI 10.1016/j.forsciint.2015.07.042
Knihovny.cz E-zdroje

"Krokodil" is the street name for a drug, which has been attracting media and researchers attention due to its increasing spread and extreme toxicity. "Krokodil" is a homemade injectable mixture being used as a cheap substitute for heroin. Its use begun in Russia and Ukraine, but it is being spread throughout other countries. The starting materials for "krokodil" synthesis are tablets containing codeine, caustic soda, gasoline, hydrochloric acid, iodine from disinfectants and red phosphorus from matchboxes, all of which are easily available in a retail market or drugstores. The resulting product is a light brown liquid that is injected without previous purification. Herein, we aimed to understand the chemistry behind "krokodil" synthesis by mimicking the steps followed by people who use this drug. The successful synthesis was assessed by the presence of desomorphine and other two morphinans. An analytical gas chromatography-electron impact/mass spectrometry (GC-EI/MS) methodology for quantification of desomorphine and codeine was also developed and validated. The methodologies presented herein provide a representative synthesis of "krokodil" street samples and the application of an effective analytical methodology for desomorphine quantification, which was the major morphinan found. Further studies are required in order to find other hypothetical by-products in "krokodil" since these may help to explain signs and symptoms presented by abusers.

Citace poskytuje Crossref.org

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