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Antifouling Polymer Brushes Displaying Antithrombogenic Surface Properties

A. de los Santos Pereira, S. Sheikh, C. Blaszykowski, O. Pop-Georgievski, K. Fedorov, M. Thompson, C. Rodriguez-Emmenegger,

. 2016 ; 17 (3) : 1179-85. [pub] 20160226

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc17000457

The contact of blood with artificial materials generally leads to immediate protein adsorption (fouling), which mediates subsequent biological processes such as platelet adhesion and activation leading to thrombosis. Recent progress in the preparation of surfaces able to prevent protein fouling offers a potential avenue to mitigate this undesirable effect. In the present contribution, we have prepared several types of state-of-the-art antifouling polymer brushes on polycarbonate plastic substrate, and investigated their ability to prevent platelet adhesion and thrombus formation under dynamic flow conditions using human blood. Moreover, we compared the ability of such brushes--grafted on quartz via an adlayer analogous to that used on polycarbonate--to prevent protein adsorption from human blood plasma, assessed for the first time by means of an ultrahigh frequency acoustic wave sensor. Results show that the prevention of such a phenomenon constitutes one promising route toward enhanced resistance to thrombus formation, and suggest that antifouling polymer brushes could be of service in biomedical applications requiring extensive blood-material surface contact.

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$a The contact of blood with artificial materials generally leads to immediate protein adsorption (fouling), which mediates subsequent biological processes such as platelet adhesion and activation leading to thrombosis. Recent progress in the preparation of surfaces able to prevent protein fouling offers a potential avenue to mitigate this undesirable effect. In the present contribution, we have prepared several types of state-of-the-art antifouling polymer brushes on polycarbonate plastic substrate, and investigated their ability to prevent platelet adhesion and thrombus formation under dynamic flow conditions using human blood. Moreover, we compared the ability of such brushes--grafted on quartz via an adlayer analogous to that used on polycarbonate--to prevent protein adsorption from human blood plasma, assessed for the first time by means of an ultrahigh frequency acoustic wave sensor. Results show that the prevention of such a phenomenon constitutes one promising route toward enhanced resistance to thrombus formation, and suggest that antifouling polymer brushes could be of service in biomedical applications requiring extensive blood-material surface contact.
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$a Sheikh, Sonia $u Department of Chemistry - St. George Campus, University of Toronto , 80 St. George Street, Toronto, Ontario Canada M5S 3H6.
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$a Blaszykowski, Christophe $u Econous Systems Inc. , 80 St. George Street, Toronto, Ontario Canada M5S 3H6.
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$a Pop-Georgievski, Ognen $u Department of Chemistry and Physics of Surfaces and Biointerfaces, Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v.v.i. , Heyrovsky Square 2, 162 06 Prague, Czech Republic.
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$a Fedorov, Kiril $u Institute of Biomaterials & Biomedical Engineering, 164 College Street, University of Toronto , Toronto, Ontario Canada M5S 3G9.
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$a Thompson, Michael $u Department of Chemistry - St. George Campus, University of Toronto , 80 St. George Street, Toronto, Ontario Canada M5S 3H6.
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$a Rodriguez-Emmenegger, Cesar $u Department of Chemistry and Physics of Surfaces and Biointerfaces, Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v.v.i. , Heyrovsky Square 2, 162 06 Prague, Czech Republic. DWI - Leibniz Institute for Interactive Materials and Institute of Technical and Macromolecular Chemistry, RWTH Aachen University , Forckenbeckstraße 50, 52074 Aachen, Germany.
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