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Effects of antitumor derivatives of ineffective transplatin on bacterial cells: Is DNA a pharmacological target
J. Kasparkova, V. Brabec,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Cisplatin chemistry pharmacology MeSH
- DNA, Bacterial chemistry MeSH
- Escherichia coli drug effects MeSH
- Organoplatinum Compounds chemistry pharmacology MeSH
- Antineoplastic Agents chemistry pharmacology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The effects of the two representatives of the antitumor transplatinum agents, trans-[PtCl2(methylamine)2] and trans-[PtCl2(NH3)(1-methyl-7-azaindole)] on bacterial growth were examined. The results show that these antitumor transplatinum agents can be grouped with the coordination Pt(II) compounds exhibiting antitumor activity and capable of inducing bacterial filamentation and initiate lysis in lysogenic bacteria. The results corroborate the thesis that DNA is the potential cellular target also for a class of antitumor derivatives of transplatin.
References provided by Crossref.org
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