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Effects of antitumor derivatives of ineffective transplatin on bacterial cells: Is DNA a pharmacological target
J. Kasparkova, V. Brabec,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- cisplatina chemie farmakologie MeSH
- DNA bakterií chemie MeSH
- Escherichia coli účinky léků MeSH
- organoplatinové sloučeniny chemie farmakologie MeSH
- protinádorové látky chemie farmakologie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The effects of the two representatives of the antitumor transplatinum agents, trans-[PtCl2(methylamine)2] and trans-[PtCl2(NH3)(1-methyl-7-azaindole)] on bacterial growth were examined. The results show that these antitumor transplatinum agents can be grouped with the coordination Pt(II) compounds exhibiting antitumor activity and capable of inducing bacterial filamentation and initiate lysis in lysogenic bacteria. The results corroborate the thesis that DNA is the potential cellular target also for a class of antitumor derivatives of transplatin.
Citace poskytuje Crossref.org
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