Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

The role of the insular cortex in naloxone-induced conditioned place aversion in morphine-dependent mice

F. Wang, X. Jing, J. Yang, H. Wang, R. Xiang, W. Han, X. Liu, C. Wu

. 2016 ; 65 (4) : 701-709. [pub] 20160315

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc17012753

A negative emotional state resulting from the withdrawal of drug addiction is thought to be an important factor that triggers and exacerbates relapse. Since the insular cortex is a key brain structure involved in the modulation of negative emotions, we investigated whether the integrity of the insular cortex was important for motivational aversion associated with morphine withdrawal as well as whether this kind of negative emotion induced neuroadaptation in the insular cortex. In this present study, a sensitive mouse conditioned place aversion (CPA) model measuring the motivational aversion of morphine withdrawal was first established. Our results showed that bilateral insular cortex lesions by kainic acid completely inhibited the expression of CPA. The expression of FosB/deltaFosB in the insular cortex was significantly increased 24 h after the CPA regime was performed, but the expression of c-Fos in the insular cortex did not changed. These findings indicate that the integrity of the insular cortex is essential to motivational aversion associated with morphine withdrawal, and that this kind of aversion induces neuroadaptation, observed as the increase of FosB/deltaFosB expression, in the insular cortex.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17012753
003      
CZ-PrNML
005      
20170424110712.0
007      
ta
008      
170412s2016 xr ad f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.933106 $2 doi
035    __
$a (PubMed)26988162
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Wang, Fang $u Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
245    14
$a The role of the insular cortex in naloxone-induced conditioned place aversion in morphine-dependent mice / $c F. Wang, X. Jing, J. Yang, H. Wang, R. Xiang, W. Han, X. Liu, C. Wu
520    9_
$a A negative emotional state resulting from the withdrawal of drug addiction is thought to be an important factor that triggers and exacerbates relapse. Since the insular cortex is a key brain structure involved in the modulation of negative emotions, we investigated whether the integrity of the insular cortex was important for motivational aversion associated with morphine withdrawal as well as whether this kind of negative emotion induced neuroadaptation in the insular cortex. In this present study, a sensitive mouse conditioned place aversion (CPA) model measuring the motivational aversion of morphine withdrawal was first established. Our results showed that bilateral insular cortex lesions by kainic acid completely inhibited the expression of CPA. The expression of FosB/deltaFosB in the insular cortex was significantly increased 24 h after the CPA regime was performed, but the expression of c-Fos in the insular cortex did not changed. These findings indicate that the integrity of the insular cortex is essential to motivational aversion associated with morphine withdrawal, and that this kind of aversion induces neuroadaptation, observed as the increase of FosB/deltaFosB expression, in the insular cortex.
650    _2
$a zvířata $7 D000818
650    _2
$a mozková kůra $x metabolismus $x patofyziologie $7 D002540
650    _2
$a modely nemocí na zvířatech $7 D004195
650    _2
$a kyselina kainová $7 D007608
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a duševní poruchy $x chemicky indukované $x metabolismus $x patofyziologie $7 D001523
650    _2
$a myši $7 D051379
650    _2
$a morfin $x škodlivé účinky $7 D009020
650    _2
$a naloxon $x analogy a deriváty $7 D009270
650    _2
$a narkotika $x škodlivé účinky $7 D009294
650    _2
$a protoonkogenní proteiny c-fos $x metabolismus $7 D016760
650    _2
$a náhodné rozdělení $7 D011897
650    _2
$a abstinenční syndrom $x metabolismus $x patofyziologie $7 D013375
655    _2
$a časopisecké články $7 D016428
700    1_
$a Jing, Xiaolong $u Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
700    1_
$a Yang, Jingyu $u Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
700    1_
$a Wang, Huan $u Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
700    1_
$a Xiang, Rongwu $u Mathematics Teaching and Research Section, Shenyang Pharmaceutical University, Shenyang, China
700    1_
$a Han, Wenyan $u Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
700    1_
$a Liu, Xinxin $u Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
700    1_
$a Wu, Chunfu $u Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 65, č. 4 (2016), s. 701-709
856    41
$u http://www.biomed.cas.cz/physiolres/ $y domovská stránka časopisu
910    __
$a ABA008 $b A 4120 $c 266 $y 4 $z 0
990    __
$a 20170412 $b ABA008
991    __
$a 20170421101542 $b ABA008
999    __
$a ok $b bmc $g 1201688 $s 973526
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 65 $c 4 $d 701-709 $e 20160315 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK118 $a Pubmed-20170412

Find record

Citation metrics

Archiving options