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MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis

M. Tomasetti, M. Amati, L. Santarelli, J. Neuzil,

. 2016 ; 17 (5) : . [pub] 20160518

Language English Country Switzerland

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc17013833

The process of metabolic re-programing is linked to the activation of oncogenes and/or suppression of tumour suppressor genes, which are regulated by microRNAs (miRNAs). The interplay between oncogenic transformation-driven metabolic re-programming and modulation of aberrant miRNAs further established their critical role in the initiation, promotion and progression of cancer by creating a tumorigenesis-prone microenvironment, thus orchestrating processes of evasion to apoptosis, angiogenesis and invasion/migration, as well metastasis. Given the involvement of miRNAs in tumour development and their global deregulation, they may be perceived as biomarkers in cancer of therapeutic relevance.

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$a Santarelli, Lory $u Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona 60020, Italy. l.santarelli@univpm.it.
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