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Primary pulmonary clear cell sarcoma-the first two reported cases
GH. Goh, M. Teh, T. Vanecek, C. Moran, F. Petersson,
Jazyk angličtina Země Německo
Typ dokumentu kazuistiky, časopisecké články
NLK
ProQuest Central
od 2003-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2011-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 2003-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2003-01-01 do Před 1 rokem
- MeSH
- genová přestavba fyziologie MeSH
- hybridizace in situ fluorescenční metody MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory měkkých tkání genetika patologie MeSH
- proteiny S100 metabolismus MeSH
- proteiny vázající kalmodulin genetika metabolismus MeSH
- proteiny vázající RNA genetika metabolismus MeSH
- sarkom z jasných buněk diagnóza genetika MeSH
- translokace genetická genetika MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
We report two cases (male patients 50 and 55 years old) of clear cell sarcoma ("melanoma of soft parts") arising in the lung, of which one case showed regional lymph node metastases. Histologically, both tumors displayed varying clear epithelioid and spindle neoplastic cells arranged in storiform and nested growth patterns, separated by thin fibrovascular septa. Immunohistochemical studies demonstrated positive expression of S-100 protein, HMB-45 and Melan-A in one case and S-100 protein only in the other. Fluorescence in situ hybridization showed positive EWSR1 gene rearrangement, and a presence of EWS-ATF1 fusion transcript was confirmed by RT-PCR and sequencing in one case.
Department of Molecular Genetics Bioptical Laboratory Ltd Pilsen Czech Republic
Department of Pathology National University Health System 5 Lower Kent Ridge Road 119074 Singapore
Department of Pathology University of Texas MD Anderson Cancer Centre Houston Texas USA
Citace poskytuje Crossref.org
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- $a We report two cases (male patients 50 and 55 years old) of clear cell sarcoma ("melanoma of soft parts") arising in the lung, of which one case showed regional lymph node metastases. Histologically, both tumors displayed varying clear epithelioid and spindle neoplastic cells arranged in storiform and nested growth patterns, separated by thin fibrovascular septa. Immunohistochemical studies demonstrated positive expression of S-100 protein, HMB-45 and Melan-A in one case and S-100 protein only in the other. Fluorescence in situ hybridization showed positive EWSR1 gene rearrangement, and a presence of EWS-ATF1 fusion transcript was confirmed by RT-PCR and sequencing in one case.
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