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Primary pulmonary clear cell sarcoma-the first two reported cases
GH. Goh, M. Teh, T. Vanecek, C. Moran, F. Petersson,
Language English Country Germany
Document type Case Reports, Journal Article
NLK
ProQuest Central
from 2003-01-01 to 1 year ago
Medline Complete (EBSCOhost)
from 2011-01-01 to 1 year ago
Nursing & Allied Health Database (ProQuest)
from 2003-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 2003-01-01 to 1 year ago
- MeSH
- Gene Rearrangement physiology MeSH
- In Situ Hybridization, Fluorescence methods MeSH
- Middle Aged MeSH
- Humans MeSH
- Soft Tissue Neoplasms genetics pathology MeSH
- S100 Proteins metabolism MeSH
- Calmodulin-Binding Proteins genetics metabolism MeSH
- RNA-Binding Proteins genetics metabolism MeSH
- Sarcoma, Clear Cell diagnosis genetics MeSH
- Translocation, Genetic genetics MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
We report two cases (male patients 50 and 55 years old) of clear cell sarcoma ("melanoma of soft parts") arising in the lung, of which one case showed regional lymph node metastases. Histologically, both tumors displayed varying clear epithelioid and spindle neoplastic cells arranged in storiform and nested growth patterns, separated by thin fibrovascular septa. Immunohistochemical studies demonstrated positive expression of S-100 protein, HMB-45 and Melan-A in one case and S-100 protein only in the other. Fluorescence in situ hybridization showed positive EWSR1 gene rearrangement, and a presence of EWS-ATF1 fusion transcript was confirmed by RT-PCR and sequencing in one case.
Department of Molecular Genetics Bioptical Laboratory Ltd Pilsen Czech Republic
Department of Pathology National University Health System 5 Lower Kent Ridge Road 119074 Singapore
Department of Pathology University of Texas MD Anderson Cancer Centre Houston Texas USA
References provided by Crossref.org
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- $a We report two cases (male patients 50 and 55 years old) of clear cell sarcoma ("melanoma of soft parts") arising in the lung, of which one case showed regional lymph node metastases. Histologically, both tumors displayed varying clear epithelioid and spindle neoplastic cells arranged in storiform and nested growth patterns, separated by thin fibrovascular septa. Immunohistochemical studies demonstrated positive expression of S-100 protein, HMB-45 and Melan-A in one case and S-100 protein only in the other. Fluorescence in situ hybridization showed positive EWSR1 gene rearrangement, and a presence of EWS-ATF1 fusion transcript was confirmed by RT-PCR and sequencing in one case.
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