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Neonatal outcomes in subgroups of women with preterm prelabor rupture of membranes before 34 weeks
M. Stepan, T. Cobo, J. Maly, M. Navratilova, I. Musilova, H. Hornychova, B. Jacobsson, M. Kacerovsky,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, pozorovací studie, práce podpořená grantem
Grantová podpora
NT13461
MZ0
CEP - Centrální evidence projektů
- MeSH
- chorioamnionitida epidemiologie mikrobiologie MeSH
- dospělí MeSH
- gestační stáří MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- novorozenec MeSH
- novorozenecká sepse epidemiologie MeSH
- plodová voda mikrobiologie MeSH
- předčasný odtok plodové vody epidemiologie MeSH
- prospektivní studie MeSH
- těhotenství MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- novorozenec MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
OBJECTIVE: To evaluate the influence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) on short-term neonatal outcome in women with preterm prelabor rupture of membranes before 34 weeks of gestation. METHODS: A prospective observational cohort study including 122 pregnant women with PPROM between 24+0 and 34+0. MIAC was defined as a positive PCR result for Ureaplasma species, Mycoplasma hominis and Chlamydia trachomatis and/or positive PCR result for the 16S rRNA gene in the amniotic fluid. HCA was defined according to the Salafia classification. Maternal and short-term neonatal outcomes were evaluated according to the presence or absence of MIAC and/or HCA. RESULTS: The presence of both MIAC and HCA was observed in 36% (45/122) of women, HCA alone in 34% (41/122) and MIAC in 5% (6/122). A significantly higher incidence of early onset sepsis was observed in newborns born from women with both MIAC and HCA [33% (15/45)] compared with women with HCA alone [12% (5/41)] or MIAC alone [0% (0/6)] or women without MIAC or HCA detected [0% (0/30); p = 0.001]. CONCLUSIONS: The presence of both MIAC and HCA increases the risk of early onset sepsis in pregnancies complicated by preterm prelabor rupture of membranes before 34 weeks of gestation.
Citace poskytuje Crossref.org
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- $a Štěpán, Martin. $u a Faculty of Medicine Hradec Kralove, Department of Obstetrics and Gynecology , Charles University in Prague , Hradec Kralove , Czech Republic . $7 xx0229256
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- $a Neonatal outcomes in subgroups of women with preterm prelabor rupture of membranes before 34 weeks / $c M. Stepan, T. Cobo, J. Maly, M. Navratilova, I. Musilova, H. Hornychova, B. Jacobsson, M. Kacerovsky,
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- $a OBJECTIVE: To evaluate the influence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) on short-term neonatal outcome in women with preterm prelabor rupture of membranes before 34 weeks of gestation. METHODS: A prospective observational cohort study including 122 pregnant women with PPROM between 24+0 and 34+0. MIAC was defined as a positive PCR result for Ureaplasma species, Mycoplasma hominis and Chlamydia trachomatis and/or positive PCR result for the 16S rRNA gene in the amniotic fluid. HCA was defined according to the Salafia classification. Maternal and short-term neonatal outcomes were evaluated according to the presence or absence of MIAC and/or HCA. RESULTS: The presence of both MIAC and HCA was observed in 36% (45/122) of women, HCA alone in 34% (41/122) and MIAC in 5% (6/122). A significantly higher incidence of early onset sepsis was observed in newborns born from women with both MIAC and HCA [33% (15/45)] compared with women with HCA alone [12% (5/41)] or MIAC alone [0% (0/6)] or women without MIAC or HCA detected [0% (0/30); p = 0.001]. CONCLUSIONS: The presence of both MIAC and HCA increases the risk of early onset sepsis in pregnancies complicated by preterm prelabor rupture of membranes before 34 weeks of gestation.
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- $a Jacobsson, Bo $u b Department of Obstetrics and Gynecology , Sahlgrenska Academy, Sahlgrenska University Hospital , Gothenburg , Sweden . f Division of Epidemiology, Department of Genes and Environment , Norwegian Institut of Public Health, Oslo University , Oslo , Norway , and.
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