-
Something wrong with this record ?
Effect of species-specific differences in chromosome morphology on chromatin compaction and the frequency and distribution of RAD51 and MLH1 foci in two bovid species: cattle (Bos taurus) and the common eland (Taurotragus oryx)
H. Sebestova, M. Vozdova, S. Kubickova, H. Cernohorska, R. Kotrba, J. Rubes,
Language English Country Austria
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
ProQuest Central
from 1997-03-01 to 1 year ago
Health & Medicine (ProQuest)
from 1997-03-01 to 1 year ago
- MeSH
- Antelopes genetics MeSH
- DNA metabolism MeSH
- Species Specificity MeSH
- DNA Breaks, Double-Stranded MeSH
- DNA Repair Enzymes genetics metabolism MeSH
- Meiosis genetics MeSH
- Gene Expression Regulation MeSH
- Recombination, Genetic MeSH
- Rad51 Recombinase genetics metabolism MeSH
- Chromosomes, Mammalian genetics metabolism ultrastructure MeSH
- DNA Packaging * MeSH
- Cattle MeSH
- Synaptonemal Complex MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Cattle MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Meiotic recombination between homologous chromosomes is crucial for their correct segregation into gametes and for generating diversity. We compared the frequency and distribution of MLH1 foci and RAD51 foci, synaptonemal complex (SC) length and DNA loop size in two related Bovidae species that share chromosome arm homology but show an extreme difference in their diploid chromosome number: cattle (Bos taurus, 2n = 60) and the common eland (Taurotragus oryx, 2nmale = 31). Compared to cattle, significantly fewer MLH1 foci per cell were observed in the common eland, which can be attributed to the lower number of initial double-strand breaks (DSBs) detected as RAD51 foci in leptonema. Despite the significantly shorter total autosomal SC length and longer DNA loop size of the common eland bi-armed chromosomes compared to those of bovine acrocentrics, the overall crossover density in the common eland was still lower than in cattle, probably due to the reduction in the number of MLH1 foci in the proximal regions of the bi-armed chromosomes. The formation of centric fusions during karyotype evolution of the common eland accompanied by meiotic chromatin compaction has greater implications in the reduction in the number of DSBs in leptonema than in the decrease of MLH1 foci number in pachynema.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc17014282
- 003
- CZ-PrNML
- 005
- 20170428122854.0
- 007
- ta
- 008
- 170413s2016 au f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1007/s00412-015-0533-x $2 doi
- 035 __
- $a (PubMed)26194101
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a au
- 100 1_
- $a Sebestova, Hana $u Central European Institute of Technology-Veterinary Research Institute, Hudcova 70, 621 00, Brno, Czech Republic.
- 245 10
- $a Effect of species-specific differences in chromosome morphology on chromatin compaction and the frequency and distribution of RAD51 and MLH1 foci in two bovid species: cattle (Bos taurus) and the common eland (Taurotragus oryx) / $c H. Sebestova, M. Vozdova, S. Kubickova, H. Cernohorska, R. Kotrba, J. Rubes,
- 520 9_
- $a Meiotic recombination between homologous chromosomes is crucial for their correct segregation into gametes and for generating diversity. We compared the frequency and distribution of MLH1 foci and RAD51 foci, synaptonemal complex (SC) length and DNA loop size in two related Bovidae species that share chromosome arm homology but show an extreme difference in their diploid chromosome number: cattle (Bos taurus, 2n = 60) and the common eland (Taurotragus oryx, 2nmale = 31). Compared to cattle, significantly fewer MLH1 foci per cell were observed in the common eland, which can be attributed to the lower number of initial double-strand breaks (DSBs) detected as RAD51 foci in leptonema. Despite the significantly shorter total autosomal SC length and longer DNA loop size of the common eland bi-armed chromosomes compared to those of bovine acrocentrics, the overall crossover density in the common eland was still lower than in cattle, probably due to the reduction in the number of MLH1 foci in the proximal regions of the bi-armed chromosomes. The formation of centric fusions during karyotype evolution of the common eland accompanied by meiotic chromatin compaction has greater implications in the reduction in the number of DSBs in leptonema than in the decrease of MLH1 foci number in pachynema.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a antilopy $x genetika $7 D000866
- 650 _2
- $a skot $7 D002417
- 650 _2
- $a savčí chromozomy $x genetika $x metabolismus $x ultrastruktura $7 D033481
- 650 _2
- $a DNA $x metabolismus $7 D004247
- 650 _2
- $a dvouřetězcové zlomy DNA $7 D053903
- 650 12
- $a sbalení DNA $7 D042003
- 650 _2
- $a enzymy opravy DNA $x genetika $x metabolismus $7 D045643
- 650 _2
- $a regulace genové exprese $7 D005786
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a meióza $x genetika $7 D008540
- 650 _2
- $a rekombinasa Rad51 $x genetika $x metabolismus $7 D051135
- 650 _2
- $a rekombinace genetická $7 D011995
- 650 _2
- $a druhová specificita $7 D013045
- 650 _2
- $a synaptonemální komplex $7 D013573
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Vozdova, Miluse $u Central European Institute of Technology-Veterinary Research Institute, Hudcova 70, 621 00, Brno, Czech Republic. vozdova@vri.cz.
- 700 1_
- $a Kubickova, Svatava $u Central European Institute of Technology-Veterinary Research Institute, Hudcova 70, 621 00, Brno, Czech Republic.
- 700 1_
- $a Cernohorska, Halina $u Central European Institute of Technology-Veterinary Research Institute, Hudcova 70, 621 00, Brno, Czech Republic.
- 700 1_
- $a Kotrba, Radim $u Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague, Kamýcká 129, 165 21, Prague, Czech Republic.
- 700 1_
- $a Rubes, Jiri $u Central European Institute of Technology-Veterinary Research Institute, Hudcova 70, 621 00, Brno, Czech Republic.
- 773 0_
- $w MED00002160 $t Chromosoma $x 1432-0886 $g Roč. 125, č. 1 (2016), s. 137-49
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/26194101 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20170413 $b ABA008
- 991 __
- $a 20170428123216 $b ABA008
- 999 __
- $a ok $b bmc $g 1200747 $s 975060
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2016 $b 125 $c 1 $d 137-49 $e 20150721 $i 1432-0886 $m Chromosoma $n Chromosoma $x MED00002160
- LZP __
- $a Pubmed-20170413
