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Successful Posaconazole Therapy of Disseminated Alternariosis due to Alternaria infectoria in a Heart Transplant Recipient
P. Lyskova, M. Kubanek, V. Hubka, E. Sticova, L. Voska, D. Kautznerova, M. Kolarik, P. Hamal, M. Vasakova,
Jazyk angličtina Země Nizozemsko
Typ dokumentu kazuistiky, časopisecké články
Perzistentní odkaz
https://www.medvik.cz/link/bmc17023489
Online
Plný text
NLK
ProQuest Central
od 1997-04-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2011-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-04-01 do Před 1 rokem
- MeSH
- Alternaria klasifikace účinky léků genetika izolace a purifikace MeSH
- antifungální látky terapeutické užití MeSH
- debridement MeSH
- dermatomykózy diagnóza farmakoterapie mikrobiologie MeSH
- DNA fungální chemie genetika MeSH
- histocytochemie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mezerníky ribozomální DNA chemie genetika MeSH
- mikroskopie MeSH
- phaeohyphomykóza diagnóza farmakoterapie mikrobiologie MeSH
- plicní mykózy diagnóza farmakoterapie mikrobiologie MeSH
- příjemce transplantátu MeSH
- sekvenční analýza DNA MeSH
- transplantace srdce MeSH
- triazoly terapeutické užití MeSH
- tubulin genetika MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
We report a case of phaeohyphomycosis caused by Alternaria infectoria in a 61-year-old heart transplant recipient with multiple skin lesions and pulmonary infiltrates. The infection spread via the haematogenous route from the primary cutaneous lesions into the lungs. The diagnosis was based on the histopathological examination, direct microscopy, skin lesion cultures and detection of Alternaria DNA in the bronchoalveolar lavage fluid using molecular methods. The treatment consisted of a combination of surgical excision and systemic antifungal therapy. Voriconazole was the first agent used but had a weak effect. Posaconazole was subsequently used to achieve a successful response. The isolate was identified as A. infectoria by sequencing of the rDNA ITS region and the partial β-tubulin gene.
Citace poskytuje Crossref.org
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- $a Lyskova, Pavlina $u Laboratory of Medical Mycology, Department of Parasitology, Mycology and Mycobacteriology Prague, Public Health Institute in Usti nad Labem, Sokolovska 60, 186 00, Prague 8, Czech Republic. pavlina.lyskova@zuusti.cz. Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Hnevotinska 3, 775 15, Olomouc, Czech Republic. pavlina.lyskova@zuusti.cz.
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- $a We report a case of phaeohyphomycosis caused by Alternaria infectoria in a 61-year-old heart transplant recipient with multiple skin lesions and pulmonary infiltrates. The infection spread via the haematogenous route from the primary cutaneous lesions into the lungs. The diagnosis was based on the histopathological examination, direct microscopy, skin lesion cultures and detection of Alternaria DNA in the bronchoalveolar lavage fluid using molecular methods. The treatment consisted of a combination of surgical excision and systemic antifungal therapy. Voriconazole was the first agent used but had a weak effect. Posaconazole was subsequently used to achieve a successful response. The isolate was identified as A. infectoria by sequencing of the rDNA ITS region and the partial β-tubulin gene.
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- $a Kubanek, Milos $u Department of Cardiology, Institute for Clinical and Experimental Medicine, Videnska 1958, 140 21, Prague 4, Czech Republic.
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