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Higher latitude is significantly associated with an earlier age of disease onset in multiple sclerosis
C. Tao, S. Simpson, I. van der Mei, L. Blizzard, E. Havrdova, D. Horakova, V. Shaygannejad, A. Lugaresi, G. Izquierdo, M. Trojano, P. Duquette, M. Girard, F. Grand'Maison, P. Grammond, R. Alroughani, M. Terzi, C. Oreja-Guevara, SA. Sajedi, G....
Language English Country England, Great Britain
Document type Comparative Study, Journal Article, Multicenter Study
NLK
ProQuest Central
from 1944-07-01 to 6 months ago
Nursing & Allied Health Database (ProQuest)
from 1944-07-01 to 6 months ago
Health & Medicine (ProQuest)
from 1944-07-01 to 6 months ago
Psychology Database (ProQuest)
from 1944-07-01 to 6 months ago
- MeSH
- Adult MeSH
- Genetic Predisposition to Disease genetics MeSH
- Genetics MeSH
- Cohort Studies MeSH
- Geography, Medical MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Multiple Sclerosis, Relapsing-Remitting diagnosis epidemiology etiology MeSH
- Risk Factors MeSH
- Multiple Sclerosis diagnosis epidemiology etiology MeSH
- Ultraviolet Rays MeSH
- Age of Onset MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Comparative Study MeSH
- Geographicals
- Australia MeSH
- Europe MeSH
BACKGROUND: Age at onset (AAO) in multiple sclerosis (MS) is an important marker of disease severity and may have prognostic significance. Understanding what factors can influence AAO may shed light on the aetiology of this complex disease, and have applications in the diagnostic process. METHODS: The study cohort of 22 162 eligible patients from 21 countries was extracted from the MSBase registry. Only patients with MS aged ≥16 years were included. To reduce heterogeneity, only centres of largely European descent were included for analysis. AAO was defined as the year of the first symptom suggestive of inflammatory central nervous system demyelination. Predictors of AAO were evaluated by linear regression. RESULTS: Compared with those living in lower latitudes (19.0-39.9°), onset of symptoms was 1.9 years earlier for those at higher latitudes (50.0-56.0°) (p=3.83×10(-23)). A reciprocal relationship was seen for ambient ultraviolet radiation (UVR), with a significantly increasing AAO for patients with MS per each quartile increment of ambient UVR (p=1.56×10(-17)). We found that the AAO of female patients was ∼5 months earlier than male patients (p=0.002). AAO of progressive-onset patients with MS were ∼9 years later than relapsing-onset patients (p=1.40×10(-265)). CONCLUSIONS: An earlier AAO in higher latitude regions was found in this worldwide European-descent cohort and correlated inversely with variation in latitudinal UVR. These results suggest that environmental factors which act at the population level may significantly influence disease severity characteristics in genetically susceptible populations.
Al Zahra Hospital Isfahan University of Medical Sciences Isfahan Iran
Amiri Hospital Kuwait City Kuwait
AORN San Giuseppe Moscati Avellino Avellino Italy
Bombay Hospital Institute of Medical Sciences Mumbai India
Brain and Mind Research Institute Sydney New South Wales Australia
C Mondino National Neurological Institute Pavia Italy
CHUM Hôpital Notre Dame Montreal Canada
CISSS Chaudiere Appalaches Levis Quebec Canada
Cliniques Universitaires Saint Luc Brussels Belgium
Department of Basic Medical Sciences Neuroscience and Sense Organs University of Bari Bari Italy
Department of Medicine Royal Melbourne Hospital University of Melbourne Melbourne Victoria Australia
Department of Neurofarba Section of Neurosciences University of Florence Florence Italy
Department of Neurology Golestan University of Medical Sciences Gorgan Iran
Department of Neurology Mayis University Samsun Turkey
Department of Neuroscience University of Parma Parma Italy
Flinders University and Medical Centre Adelaide South Australia Australia
Geelong Hospital Geelong Victoria Australia
Groene Hart Ziekenhuis Gouda The Netherlands
Hospital de Galdakao Usansolo Galdakao Spain
Hospital Ecoville Curitiba Brazil
Hospital Fernandez Capital Federal Argentina
Hospital Germans Trias 1 Pujol Badalona Spain
Hospital Italiano Buenos Aries Argentina
Hospital Universitario Virgen de Valme Sevilla Spain
Hospital Universitario Virgen Macarena Sevilla Spain
Liverpool Hospital Liverpool New South Wales Australia
Menzies Institute for Medical Research University of Tasmania Hobart Tasmania Australia
Neuro Rive Sud Hôpital Charles LeMoyne Quebec Quebec Canada
Neurology Unit ASUR Marche AV 3 Macerata Italy
Ospedali Riuniti di Salerno Salerno Italy
St Andrew's Place Brisbane Australia
St Vincent's Hospital Melbourne Victoria Australia
References provided by Crossref.org
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