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The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

M. Benchekroun, A. Romero, J. Egea, R. León, P. Michalska, I. Buendía, ML. Jimeno, D. Jun, J. Janockova, V. Sepsova, O. Soukup, OM. Bautista-Aguilera, B. Refouvelet, O. Ouari, J. Marco-Contelles, L. Ismaili,

. 2016 ; 59 (21) : 9967-9973. [pub] 20161031

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17023558

Novel multifunctional tacrines for Alzheimer's disease were obtained by Ugi-reaction between ferulic (or lipoic acid), a melatonin-like isocyanide, formaldehyde, and tacrine derivatives, according to the antioxidant additive approach in order to modulate the oxidative stress as therapeutic strategy. Compound 5c has been identified as a promising permeable agent showing excellent antioxidant properties, strong cholinesterase inhibitory activity, less hepatotoxicity than tacrine, and the best neuroprotective capacity, being able to significantly activate the Nrf2 transcriptional pathway.

Citace poskytuje Crossref.org

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