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Fabrication of biodegradable textile scaffold based on hydrophobized hyaluronic acid
V. Zapotocky, M. Pospisilova, K. Janouchova, D. Svadlak, J. Batova, J. Sogorkova, M. Cepa, J. Betak, V. Stepankova, R. Sulakova, J. Kulhanek, T. Pitucha, J. Vranova, G. Duffy, V. Velebny,
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články
- MeSH
- biokompatibilní materiály chemie metabolismus farmakologie MeSH
- buněčná adheze účinky léků MeSH
- fibroblasty cytologie účinky léků MeSH
- hydrofobní a hydrofilní interakce * MeSH
- kyselina hyaluronová chemie metabolismus farmakologie MeSH
- lidé MeSH
- povrchové vlastnosti MeSH
- textilie * MeSH
- tkáňové inženýrství MeSH
- tkáňové podpůrné struktury chemie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
In this work, we report on the preparation of a novel biodegradable textile scaffold made of palmitoyl-hyaluronan (palHA). Monofilament fibres of palHA with a diameter of 120μm were prepared by wet spinning. The wet-spun fibres were subsequently processed into a warp-knitted textile. To find a compromise between swelling in water and degradability of the final textile scaffold, a series of palHA derivatives with different degrees of substitution of the palmitoyl chain was synthesized. Freeze-drying not only provided shape fixation, but also speeded up scaffold degradation in vitro. Fibronectin, fibrinogen, laminin and collagen IV were physically adsorbed on the textile surface to enhance cell adhesion on the material. The highest amount of adsorbed cell-adhesive proteins was achieved with fibronectin (89%), followed by fibrinogen (81%). Finally, textiles modified with fibronectin or fibrinogen both supported the adhesion and proliferation of normal human fibroblasts in vitro, proving to be a useful cellular scaffold for tissue engineering.
Advanced Materials and Bioengineering Research Centre RCSI and TCD Dublin Ireland
Contipro a s Dolní Dobrouč 401 561 02 Dolní Dobrouč Czechia
Trinity Centre for Bioengineering Trinity College Dublin Dublin Ireland
Citace poskytuje Crossref.org
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- $a In this work, we report on the preparation of a novel biodegradable textile scaffold made of palmitoyl-hyaluronan (palHA). Monofilament fibres of palHA with a diameter of 120μm were prepared by wet spinning. The wet-spun fibres were subsequently processed into a warp-knitted textile. To find a compromise between swelling in water and degradability of the final textile scaffold, a series of palHA derivatives with different degrees of substitution of the palmitoyl chain was synthesized. Freeze-drying not only provided shape fixation, but also speeded up scaffold degradation in vitro. Fibronectin, fibrinogen, laminin and collagen IV were physically adsorbed on the textile surface to enhance cell adhesion on the material. The highest amount of adsorbed cell-adhesive proteins was achieved with fibronectin (89%), followed by fibrinogen (81%). Finally, textiles modified with fibronectin or fibrinogen both supported the adhesion and proliferation of normal human fibroblasts in vitro, proving to be a useful cellular scaffold for tissue engineering.
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