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The use of Zymosan A and bacteria anchored to tumor cells for effective cancer immunotherapy: B16-F10 murine melanoma model
E. Waldmannová, V. Caisová, J. Fáberová, P. Sváčková, M. Kovářová, D. Sváčková, Z. Kumžáková, A. Jačková, N. Vácová, P. Nedbalová, M. Horká, J. Kopecký, J. Ženka,
International immunopharmacology.
2016 ;
39 (-) :
295-306.
[pub] 20160806
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články
Perzistentní odkaz
https://www.medvik.cz/link/bmc17023788
- MeSH
- buňky NK imunologie MeSH
- fagocytóza MeSH
- imunita MeSH
- imunomodulace MeSH
- imunoterapie metody MeSH
- lidé MeSH
- Listeria monocytogenes chemie imunologie MeSH
- melanom experimentální MeSH
- melanom imunologie terapie MeSH
- Mycobacterium tuberculosis chemie imunologie MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- nádory kůže imunologie terapie MeSH
- neutrofily imunologie MeSH
- protinádorové látky terapeutické užití MeSH
- transplantace nádorů MeSH
- tumor burden MeSH
- vysoká teplota MeSH
- zvířata MeSH
- zymosan chemie terapeutické užití MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
The idea of using killed microorganisms or their parts for a stimulation of immunity in the cancer immunotherapy is very old, but the question of interactions and binding of these preparations to tumor cells has not been addressed so far. The attachment of Zymosan A and both Gram-positive and Gram-negative bacteria to tumor cells was tested in in vivo experiments. This binding was accomplished by charge interactions, anchoring based on hydrophobic chains and covalent bonds and proved to be crucial for a strong immunotherapeutic effect. The establishment of conditions for simultaneous stimulation of both Toll-like and phagocytic receptors led to very strong synergy. It resulted in tumor shrinkage and its temporary or permanent elimination. The role of neutrophils in cancer immunotherapy was demonstrated and the mechanism of their action (frustrated phagocytosis) was proposed. Finally, therapeutic approaches applicable for safe human cancer immunotherapy are discussed. Heat killed Mycobacterium tuberculosis covalently attached to tumor cells seems to be promising tool for this therapy.
Citace poskytuje Crossref.org
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