-
Something wrong with this record ?
Formulation and dissolution kinetics study of hydrophilic matrix tablets with tramadol hydrochloride and different co-processed dry binders
A. Komersová, V. Lochař, K. Myslíková, J. Mužíková, M. Bartoš,
Language English Country Netherlands
Document type Journal Article
- MeSH
- Hypromellose Derivatives chemistry pharmacokinetics MeSH
- Chemistry, Pharmaceutical methods MeSH
- Hydrophobic and Hydrophilic Interactions * MeSH
- Solubility MeSH
- Tablets MeSH
- Tramadol chemistry pharmacokinetics MeSH
- Drug Liberation MeSH
- Publication type
- Journal Article MeSH
The aim of this study is to present the possibility of using of co-processed dry binders for formulation of matrix tablets with drug controlled release. Hydrophilic matrix tablets with tramadol hydrochloride, hypromellose and different co-processed dry binders were prepared by direct compression method. Hypromelloses Methocel™ K4M Premium CR or Methocel™ K100M Premium CR were used as controlled release agents and Prosolv® SMCC 90 or Disintequik™ MCC 25 were used as co-processed dry binders. Homogeneity of the tablets was evaluated using scanning electron microscopy and energy dispersive X-ray microanalysis. The release of tramadol hydrochloride from prepared formulations was studied by dissolution test method. The dissolution profiles obtained were evaluated by non-linear regression analysis, release rate constants and other kinetic parameters were determined. It was found that matrix tablets based on Prosolv® SMCC 90 and Methocel™ Premium CR cannot control the tramadol release effectively for >12h and tablets containing Disintequik™ MCC 25 and Methocel™ Premium CR >8h.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc17023803
- 003
- CZ-PrNML
- 005
- 20170720123150.0
- 007
- ta
- 008
- 170720s2016 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.ejps.2016.08.002 $2 doi
- 035 __
- $a (PubMed)27496049
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Komersová, Alena $u Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech Republic.
- 245 10
- $a Formulation and dissolution kinetics study of hydrophilic matrix tablets with tramadol hydrochloride and different co-processed dry binders / $c A. Komersová, V. Lochař, K. Myslíková, J. Mužíková, M. Bartoš,
- 520 9_
- $a The aim of this study is to present the possibility of using of co-processed dry binders for formulation of matrix tablets with drug controlled release. Hydrophilic matrix tablets with tramadol hydrochloride, hypromellose and different co-processed dry binders were prepared by direct compression method. Hypromelloses Methocel™ K4M Premium CR or Methocel™ K100M Premium CR were used as controlled release agents and Prosolv® SMCC 90 or Disintequik™ MCC 25 were used as co-processed dry binders. Homogeneity of the tablets was evaluated using scanning electron microscopy and energy dispersive X-ray microanalysis. The release of tramadol hydrochloride from prepared formulations was studied by dissolution test method. The dissolution profiles obtained were evaluated by non-linear regression analysis, release rate constants and other kinetic parameters were determined. It was found that matrix tablets based on Prosolv® SMCC 90 and Methocel™ Premium CR cannot control the tramadol release effectively for >12h and tablets containing Disintequik™ MCC 25 and Methocel™ Premium CR >8h.
- 650 _2
- $a farmaceutická chemie $x metody $7 D002626
- 650 _2
- $a uvolňování léčiv $7 D065546
- 650 12
- $a hydrofobní a hydrofilní interakce $7 D057927
- 650 _2
- $a deriváty hypromelózy $x chemie $x farmakokinetika $7 D065347
- 650 _2
- $a rozpustnost $7 D012995
- 650 _2
- $a tablety $7 D013607
- 650 _2
- $a tramadol $x chemie $x farmakokinetika $7 D014147
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Lochař, Václav $u Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech Republic. Electronic address: vaclav.lochar@upce.cz.
- 700 1_
- $a Myslíková, Kateřina $u Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech Republic.
- 700 1_
- $a Mužíková, Jitka $u Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
- 700 1_
- $a Bartoš, Martin $u Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech Republic.
- 773 0_
- $w MED00001639 $t European journal of pharmaceutical sciences official journal of the European Federation for Pharmaceutical Sciences $x 1879-0720 $g Roč. 95, č. - (2016), s. 36-45
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/27496049 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20170720 $b ABA008
- 991 __
- $a 20170720123643 $b ABA008
- 999 __
- $a ok $b bmc $g 1239484 $s 984716
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2016 $b 95 $c - $d 36-45 $e 20160803 $i 1879-0720 $m European journal of pharmaceutical sciences $n Eur. j. pharm. sci. (Print) $x MED00001639
- LZP __
- $a Pubmed-20170720
