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Assessing Host-Virus Codivergence for Close Relatives of Merkel Cell Polyomavirus Infecting African Great Apes
NF. Madinda, B. Ehlers, JO. Wertheim, C. Akoua-Koffi, RA. Bergl, C. Boesch, DB. Akonkwa, W. Eckardt, B. Fruth, TR. Gillespie, M. Gray, G. Hohmann, S. Karhemere, D. Kujirakwinja, K. Langergraber, JJ. Muyembe, R. Nishuli, M. Pauly, KJ. Petrzelkova,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
NLK
Free Medical Journals
od 1967 do Před 6 měsíci
Freely Accessible Science Journals
od 1967 do Před 6 měsíci
PubMed Central
od 1967 do Před 1 rokem
Europe PubMed Central
od 1967 do Před 6 měsíci
Open Access Digital Library
od 1967-02-01
Open Access Digital Library
od 1967-02-01
PubMed
27440885
DOI
10.1128/jvi.00247-16
Knihovny.cz E-zdroje
- MeSH
- genetická variace * MeSH
- Hominidae MeSH
- hostitelská specificita * MeSH
- infekce onkogenními viry veterinární virologie MeSH
- Merkelův polyomavirus klasifikace genetika izolace a purifikace fyziologie MeSH
- molekulární evoluce * MeSH
- polyomavirové infekce veterinární virologie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Afrika MeSH
UNLABELLED: It has long been hypothesized that polyomaviruses (PyV; family Polyomaviridae) codiverged with their animal hosts. In contrast, recent analyses suggested that codivergence may only marginally influence the evolution of PyV. We reassess this question by focusing on a single lineage of PyV infecting hominine hosts, the Merkel cell polyomavirus (MCPyV) lineage. By characterizing the genetic diversity of these viruses in seven African great ape taxa, we show that they exhibit very strong host specificity. Reconciliation analyses identify more codivergence than noncodivergence events. In addition, we find that a number of host and PyV divergence events are synchronous. Collectively, our results support codivergence as the dominant process at play during the evolution of the MCPyV lineage. More generally, our results add to the growing body of evidence suggesting an ancient and stable association of PyV and their animal hosts. IMPORTANCE: The processes involved in viral evolution and the interaction of viruses with their hosts are of great scientific interest and public health relevance. It has long been thought that the genetic diversity of double-stranded DNA viruses was generated over long periods of time, similar to typical host evolutionary timescales. This was also hypothesized for polyomaviruses (family Polyomaviridae), a group comprising several human pathogens, but this remains a point of controversy. Here, we investigate this question by focusing on a single lineage of polyomaviruses that infect both humans and their closest relatives, the African great apes. We show that these viruses exhibit considerable host specificity and that their evolution largely mirrors that of their hosts, suggesting that codivergence with their hosts played a major role in their diversification. Our results provide statistical evidence in favor of an association of polyomaviruses and their hosts over millions of years.
Department of Medicine University of California San Diego California USA
Department of Primatology Max Planck Institute for Evolutionary Anthropology Leipzig Germany
Epidemiology of Highly Pathogenic Microorganisms Robert Koch Institute Berlin Germany
Institut Congolais pour la Conservation de la Nature Kinshasa Democratic Republic of Congo
Institut National de Recherche Biomédicale Kinshasa Democratic Republic of Congo
International Gorilla Conservation Program Kigali Rwanda
North Carolina Zoological Park Asheboro North Carolina USA
Wildlife Conservation Society Grauer's Gorilla Project Kinshasa Gombe Democratic Republic of Congo
World Wildlife Foundation Dzanga Sangha Protected Areas Bangui Central African Republic
Citace poskytuje Crossref.org
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- $a Madinda, Nadège F $u Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany Institut de Recherches en Ecologie Tropicale, Libreville, Gabon.
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