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Plasma C16-Cer levels are increased in patients with preterm labor
P. Laudanski, K. Charkiewicz, R. Kisielewski, P. Kuc, E. Koc-Zorawska, G. Raba, J. Kraczkowski, V. Dymicka-Piekarska, A. Chabowski, M. Kacerovsky, B. Jacobsson, P. Zabielski, A. Blachnio-Zabielska,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- biologické markery krev MeSH
- ceramidy krev MeSH
- dospělí MeSH
- gestační stáří MeSH
- lidé MeSH
- novorozenec nedonošený MeSH
- předčasná porodní činnost krev diagnóza patofyziologie MeSH
- senzitivita a specificita MeSH
- studie případů a kontrol MeSH
- tandemová hmotnostní spektrometrie MeSH
- těhotenství MeSH
- vysokoúčinná kapalinová chromatografie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
INTRODUCTION: The pathogenesis of preterm labor is fragmentarily explained. The most widely accepted theory points out to infection and inflammation as possible causes, which can be mediated by potentially different factors, including sphingolipid mediators. Sphingolipids are a class of lipids that have been shown as important mediators in various cell processes such as: proliferation, growth, apoptosis, stress response, necrosis and inflammation. The aim of the study was to assess plasma concentrations of selected sphingolipids in patients with preterm labor. MATERIAL AND METHODS: We used ultra-high performance liquid chromatography with triple mass spectrometry (UHPLC-ESI-MS/MS) to assess plasma concentrations of the 11 sphingolipids in patients presenting with symptoms of preterm labor (n=61) and threatened preterm labor (n=40). RESULTS: We observed a statistically significant increase (p-value<0.004) in plasma concentrations of C16-Cer in patients with preterm labor as compared to the control group. We also found C16-Cer to be the best predictor of preterm labor in the group of patients with symptoms occurring after 32 weeks of gestation. CONCLUSIONS: Our findings show a possible involvement of selected sphingolipids, especially C16-Cer, in the pathogenesis of preterm labor. Their role as predictors of preterm delivery needs to be validated in the future on larger group of patients.
Biomedical Research Center University Hospital Hradec Kralove Hradec Kralove Czech Republic
Department of Physiology Medical University of Bialystok ul Mickiewicza 2C 15 222 Bialystok Poland
Institute of Obstetric and Emergency Medicine University of Rzeszow 37 710 Zurawica Poland
Citace poskytuje Crossref.org
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- $a Laudanski, Piotr $u Department of Perinatology, Medical University of Bialystok, ul. Marii Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland. Electronic address: plauda@umb.edu.pl.
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- $a Plasma C16-Cer levels are increased in patients with preterm labor / $c P. Laudanski, K. Charkiewicz, R. Kisielewski, P. Kuc, E. Koc-Zorawska, G. Raba, J. Kraczkowski, V. Dymicka-Piekarska, A. Chabowski, M. Kacerovsky, B. Jacobsson, P. Zabielski, A. Blachnio-Zabielska,
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- $a INTRODUCTION: The pathogenesis of preterm labor is fragmentarily explained. The most widely accepted theory points out to infection and inflammation as possible causes, which can be mediated by potentially different factors, including sphingolipid mediators. Sphingolipids are a class of lipids that have been shown as important mediators in various cell processes such as: proliferation, growth, apoptosis, stress response, necrosis and inflammation. The aim of the study was to assess plasma concentrations of selected sphingolipids in patients with preterm labor. MATERIAL AND METHODS: We used ultra-high performance liquid chromatography with triple mass spectrometry (UHPLC-ESI-MS/MS) to assess plasma concentrations of the 11 sphingolipids in patients presenting with symptoms of preterm labor (n=61) and threatened preterm labor (n=40). RESULTS: We observed a statistically significant increase (p-value<0.004) in plasma concentrations of C16-Cer in patients with preterm labor as compared to the control group. We also found C16-Cer to be the best predictor of preterm labor in the group of patients with symptoms occurring after 32 weeks of gestation. CONCLUSIONS: Our findings show a possible involvement of selected sphingolipids, especially C16-Cer, in the pathogenesis of preterm labor. Their role as predictors of preterm delivery needs to be validated in the future on larger group of patients.
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- $a Charkiewicz, Karol $u Department of Perinatology, Medical University of Bialystok, ul. Marii Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland.
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- $a Jacobsson, Bo $u Department of Obstetrics and Gynecology, Institute for the Health of Women and Children, Sahlgrenska University Hospital, Göteborg, Sweden; Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
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- $a Zabielski, Piotr $u Department of Physiology, Medical University of Bialystok, ul. Mickiewicza 2C, 15-222 Bialystok, Poland.
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