Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Resveratrol alleviates ethanol-induced hormonal and metabolic disturbances in the rat

K. Szkudelska, M. Deniziak, P. Roś, K. Gwóźdź, T. Szkudelski

. 2017 ; 66 (1) : 135-145. [pub] 20161026

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17026026

Resveratrol is a polyphenol found in different plant species and having numerous health-promoting properties in animals and humans. However, its protective action against deleterious effects of ethanol is poorly elucidated. In the present study, the influence of resveratrol (10 mg/kg/day) on some hormones and metabolic parameters was determined in rats ingesting 10 % ethanol solution for two weeks. Blood levels of insulin, glucagon and adiponectin were affected by ethanol, however, resveratrol partially ameliorated these changes. Moreover, in ethanol drinking rats, liver lipid accumulation was increased, whereas resveratrol was capable of reducing liver lipid content, probably due to decrease in fatty acid synthesis. Resveratrol decreased also blood levels of triglycerides and free fatty acids and reduced gamma-glutamyl transferase activity in animals ingesting ethanol. These results show that resveratrol, already at low dose, alleviates hormonal and metabolic changes induced by ethanol in the rat and may be useful in preventing and treating some consequences of alcohol consumption.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17026026
003      
CZ-PrNML
005      
20170906123123.0
007      
ta
008      
170824s2017 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.933335 $2 doi
035    __
$a (PubMed)27782737
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Szkudelska, K. $u Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, Poznan, Poland
245    10
$a Resveratrol alleviates ethanol-induced hormonal and metabolic disturbances in the rat / $c K. Szkudelska, M. Deniziak, P. Roś, K. Gwóźdź, T. Szkudelski
520    9_
$a Resveratrol is a polyphenol found in different plant species and having numerous health-promoting properties in animals and humans. However, its protective action against deleterious effects of ethanol is poorly elucidated. In the present study, the influence of resveratrol (10 mg/kg/day) on some hormones and metabolic parameters was determined in rats ingesting 10 % ethanol solution for two weeks. Blood levels of insulin, glucagon and adiponectin were affected by ethanol, however, resveratrol partially ameliorated these changes. Moreover, in ethanol drinking rats, liver lipid accumulation was increased, whereas resveratrol was capable of reducing liver lipid content, probably due to decrease in fatty acid synthesis. Resveratrol decreased also blood levels of triglycerides and free fatty acids and reduced gamma-glutamyl transferase activity in animals ingesting ethanol. These results show that resveratrol, already at low dose, alleviates hormonal and metabolic changes induced by ethanol in the rat and may be useful in preventing and treating some consequences of alcohol consumption.
650    _2
$a adiponektin $x krev $7 D052242
650    _2
$a zvířata $7 D000818
650    _2
$a ethanol $x aplikace a dávkování $x toxicita $7 D000431
650    _2
$a kyseliny mastné neesterifikované $x krev $7 D005230
650    _2
$a glukagon $x krev $7 D005934
650    _2
$a inzulin $x krev $7 D007328
650    _2
$a metabolismus lipidů $x účinky léků $x fyziologie $7 D050356
650    _2
$a játra $x účinky léků $x metabolismus $7 D008099
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a potkani Wistar $7 D017208
650    _2
$a stilbeny $x farmakologie $7 D013267
650    _2
$a triglyceridy $x krev $7 D014280
655    _2
$a časopisecké články $7 D016428
700    1_
$a Deniziak, M. $u Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszów, Poland
700    1_
$a Roś, P. $u Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszów, Poland
700    1_
$a Gwóźdź, K. $u Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, Poznan, Poland
700    1_
$a Szkudelski, T. $u Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, Poznan, Poland
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 66, č. 1 (2017), s. 135-145
856    41
$u http://www.biomed.cas.cz/physiolres/ $y stránka časopisu
910    __
$a ABA008 $b A 4120 $c 266 $y 4 $z 0
990    __
$a 20170824 $b ABA008
991    __
$a 20170905083253 $b ABA008
999    __
$a ok $b bmc $g 1246223 $s 986974
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 66 $c 1 $d 135-145 $e 20161026 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK118 $a Pubmed-20170824

Najít záznam

Citační ukazatele

Možnosti archivace