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Cyr61 Expression Pattern and Association with Clinicopathological Factors in Patients with Cervical Cancer

S. Mayer, B. Gabriel, T. Erbes, S. Timme-Bronsert, M. Jäger, G. Rücker, F. Kuf, J. Bouda, A. Bartakova, AZ. Hausen, E. Stickeler, G. Gitsch, M. Hirschfeld,

. 2017 ; 37 (5) : 2451-2456.

Jazyk angličtina Země Řecko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17030828

BACKGROUND/AIM: The pro-angiogenic Cyr61 protein has been associated with tumorigenesis and cancer progression in different gynecological carcinomas. In this study, we evaluated the potential impact and clinical relevance of Cyr61 expression in patients with primary non-metastatic cervical cancer (CC). PATIENTS AND METHODS: Cyr61 expression was assessed in tissue specimen of 48 patients with primary CC by immunohistochemical analysis. Expression levels were scored and correlated to clinico-pathological factors and outcome data. RESULTS: High Cyr61 expression levels were present in 54.2% of CC tissues. Associations with histological grade (p=0.030), depth of tumor invasion (p=0.007) and GOG score (p=0.027) were observed. Patients who overexpressed Cyr61 displayed an increased death rate (30.8% vs. 18.2%) and a decreased 5-year-survival (76.9% vs. 86.4%). CONCLUSION: Our data indicate a potential functional impact of Cyr61 in development and the progression of CC. The definite tumor-relevant function (suppressive/promoting) of Cyr61 in CC and the prognostic relevance of Cyr61 overexpression has to be evaluated in larger cohorts.

Citace poskytuje Crossref.org

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$a BACKGROUND/AIM: The pro-angiogenic Cyr61 protein has been associated with tumorigenesis and cancer progression in different gynecological carcinomas. In this study, we evaluated the potential impact and clinical relevance of Cyr61 expression in patients with primary non-metastatic cervical cancer (CC). PATIENTS AND METHODS: Cyr61 expression was assessed in tissue specimen of 48 patients with primary CC by immunohistochemical analysis. Expression levels were scored and correlated to clinico-pathological factors and outcome data. RESULTS: High Cyr61 expression levels were present in 54.2% of CC tissues. Associations with histological grade (p=0.030), depth of tumor invasion (p=0.007) and GOG score (p=0.027) were observed. Patients who overexpressed Cyr61 displayed an increased death rate (30.8% vs. 18.2%) and a decreased 5-year-survival (76.9% vs. 86.4%). CONCLUSION: Our data indicate a potential functional impact of Cyr61 in development and the progression of CC. The definite tumor-relevant function (suppressive/promoting) of Cyr61 in CC and the prognostic relevance of Cyr61 overexpression has to be evaluated in larger cohorts.
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$a Timme-Bronsert, Sylvia $u Faculty of Medicine, University of Freiburg, Freiburg, Germany. Institute of Surgical Pathology, Department of Pathology, Medical Center - University of Freiburg, Freiburg, Germany.
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$a Jäger, Markus $u Department of Obstetrics and Gynecology, Medical Center - University of Freiburg, Freiburg, Germany. Faculty of Medicine, University of Freiburg, Freiburg, Germany.
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$a Rücker, Gerta $u Faculty of Medicine, University of Freiburg, Freiburg, Germany. Institute for Medical Biometry and Statistics, Medical Center - University of Freiburg, Freiburg, Germany.
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$a Kuf, Franciska $u Department of Obstetrics and Gynecology, Medical Center - University of Freiburg, Freiburg, Germany. Faculty of Medicine, University of Freiburg, Freiburg, Germany.
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$a Bouda, Jiri $u Department of Obstetrics and Gynecology, Medical Faculty Hospital Pilsen, Charles University Prague, Plzen, Czech Republic.
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$a Hausen, Axel Zur $u Department of Pathology, Maastricht University Medical Center, Maastricht, the Netherlands.
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$a Stickeler, Elmar $u Department of Gynecology and Obstetrics, University Medical Center RWTH Aachen, Aachen, Germany.
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$a Gitsch, Gerald $u Department of Obstetrics and Gynecology, Medical Center - University of Freiburg, Freiburg, Germany. Faculty of Medicine, University of Freiburg, Freiburg, Germany.
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$a Hirschfeld, Marc $u Department of Obstetrics and Gynecology, Medical Center - University of Freiburg, Freiburg, Germany. Faculty of Medicine, University of Freiburg, Freiburg, Germany. Institute of Veterinary Medicine, Georg-August-University Goettingen, Goettingen, Germany.
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